The axonal transport of βIII-tubulin is altered in both branches of sensory axons after injury of the rat sciatic nerve

Paul N. Hoffman; Richard F. Luduena

doi:10.1016/0006-8993(95)01433-0

The axonal transport of β_III-tubulin is altered in both branches of sensory axons after injury of the rat sciatic nerve

Paul N. Hoffman, Richard F. Luduena

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We have analyzed the axonal transport of β_III-tubulin in the central (dorsal root) and peripheral (sciatic nerve) branches of sensory axons after injury of the sciatic nerve. Our finding that the relative amount of β_III-tubulin transported in slow component b (SCb) is increased in both axonal branches does not support the generally accepted hypothesis that the transport of cytoskeletal proteins is altered in the peripheral, but not the central branch after injury of the sciatic nerve.

Original language	English (US)
Pages (from-to)	182-184
Number of pages	3
Journal	Brain research
Volume	708
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(95)01433-0
State	Published - Feb 5 1996
Externally published	Yes

Keywords

Axon regeneration
Axonal transport
Axotomy
Cytoskeleton
Dorsal root
Sciatic nerve
Sensory neuron
β-Tubulin

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(95)01433-0

Cite this

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title = "The axonal transport of βIII-tubulin is altered in both branches of sensory axons after injury of the rat sciatic nerve",

abstract = "We have analyzed the axonal transport of βIII-tubulin in the central (dorsal root) and peripheral (sciatic nerve) branches of sensory axons after injury of the sciatic nerve. Our finding that the relative amount of βIII-tubulin transported in slow component b (SCb) is increased in both axonal branches does not support the generally accepted hypothesis that the transport of cytoskeletal proteins is altered in the peripheral, but not the central branch after injury of the sciatic nerve.",

keywords = "Axon regeneration, Axonal transport, Axotomy, Cytoskeleton, Dorsal root, Sciatic nerve, Sensory neuron, β-Tubulin",

author = "Hoffman, {Paul N.} and Luduena, {Richard F.}",

note = "Funding Information: We thankA nn M. Urban and BrookeE . Ratliff for their excellentte chnicaal ssistanceT.h is work was supportebdy grants NS 22849, NS 32724, NS14784, and GM23476 from the NationalI nstituteos f Healtha nd Welch Foundation GrantA Q-0726.",

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doi = "10.1016/0006-8993(95)01433-0",

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T1 - The axonal transport of βIII-tubulin is altered in both branches of sensory axons after injury of the rat sciatic nerve

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AU - Luduena, Richard F.

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N2 - We have analyzed the axonal transport of βIII-tubulin in the central (dorsal root) and peripheral (sciatic nerve) branches of sensory axons after injury of the sciatic nerve. Our finding that the relative amount of βIII-tubulin transported in slow component b (SCb) is increased in both axonal branches does not support the generally accepted hypothesis that the transport of cytoskeletal proteins is altered in the peripheral, but not the central branch after injury of the sciatic nerve.

AB - We have analyzed the axonal transport of βIII-tubulin in the central (dorsal root) and peripheral (sciatic nerve) branches of sensory axons after injury of the sciatic nerve. Our finding that the relative amount of βIII-tubulin transported in slow component b (SCb) is increased in both axonal branches does not support the generally accepted hypothesis that the transport of cytoskeletal proteins is altered in the peripheral, but not the central branch after injury of the sciatic nerve.

KW - Axon regeneration

KW - Axonal transport

KW - Axotomy

KW - Cytoskeleton

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KW - Sensory neuron

KW - β-Tubulin

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