The axonal pathology in chronic IDPN intoxication

Arthur W. Clark, John W. Griffin, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with β,β'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of this functional abnormality is a series of changes in axonal morphology: Neurofilaments accumulate in the proximal axon; the proximal axon becomes swollen; the distal axon loses volume (axonal atrophy). These studies indicate that axonal atrophy occurs secondary to an impairment of slow axonal transport and suggest that a similar abnormality may underlie the pathological changes in certain other degenerative and toxic diseases of the nervous system.

Original languageEnglish (US)
Pages (from-to)42-55
Number of pages14
JournalJournal of Neuropathology and Experimental Neurology
Volume39
Issue number1
StatePublished - 1980

Fingerprint

Axons
Axonal Transport
Intermediate Filaments
Poisons
Pathology
Atrophy
Nervous System Diseases
Neurodegenerative Diseases

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Clark, A. W., Griffin, J. W., & Price, D. L. (1980). The axonal pathology in chronic IDPN intoxication. Journal of Neuropathology and Experimental Neurology, 39(1), 42-55.

The axonal pathology in chronic IDPN intoxication. / Clark, Arthur W.; Griffin, John W.; Price, Donald L.

In: Journal of Neuropathology and Experimental Neurology, Vol. 39, No. 1, 1980, p. 42-55.

Research output: Contribution to journalArticle

Clark, AW, Griffin, JW & Price, DL 1980, 'The axonal pathology in chronic IDPN intoxication', Journal of Neuropathology and Experimental Neurology, vol. 39, no. 1, pp. 42-55.
Clark, Arthur W. ; Griffin, John W. ; Price, Donald L. / The axonal pathology in chronic IDPN intoxication. In: Journal of Neuropathology and Experimental Neurology. 1980 ; Vol. 39, No. 1. pp. 42-55.
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