The axonal pathology in chronic IDPN intoxication

Arthur W. Clark, John W. Griffin, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with β,β'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of this functional abnormality is a series of changes in axonal morphology: Neurofilaments accumulate in the proximal axon; the proximal axon becomes swollen; the distal axon loses volume (axonal atrophy). These studies indicate that axonal atrophy occurs secondary to an impairment of slow axonal transport and suggest that a similar abnormality may underlie the pathological changes in certain other degenerative and toxic diseases of the nervous system.

Original languageEnglish (US)
Pages (from-to)42-55
Number of pages14
JournalJournal of neuropathology and experimental neurology
Volume39
Issue number1
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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