The autoimmune myopathies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The autoimmune myopathies (also known as myositis) comprise a group of disorders in which skeletal muscle is one of the primary targets of the autoimmune response. The immune responses in these disorders target a limited set of ubiquitously expressed autoantigens, and there is a striking association of specific autoantibodies with distinct clinical phenotypes. Several features of these diseases, including the association with cancer, the induction of disease in response to statins, and the preferential expression of myositis-specific autoantigens in regenerating muscle cells, have provided important insights into the initiating and propagating mechanisms. Emerging data suggests a model of disease in which initiation and propagation may be separated in time and potentially space. In this model, the increased expression of myositis-specific autoantigens in regenerating cells focuses immune injury on cells healing muscle injury, establishing a self-sustaining loop of immune-mediated muscle injury and repair. Such loops may be amenable to novel therapeutic interventions.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
PublisherElsevier
Pages703-713
Number of pages11
ISBN (Electronic)9780128121023
ISBN (Print)9780128122426
DOIs
StatePublished - Jan 1 2019

Keywords

  • Aminoacyl-tRNA synthetases
  • Autoimmune myopathy
  • Cancer
  • Feedforward cycle
  • Immune-mediated necrotizing myopathy
  • Myositis
  • Myositis-specific autoantibodies
  • Paraneoplastic
  • Regeneration
  • Statins

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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