TY - JOUR
T1 - The atherosclerosis risk in communities (ARIL) study introduction and objectives of the hemostasis component
AU - Richey Sharrett, A.
N1 - Funding Information:
From the Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Nattonal Institutes of Health, Bethesda, MD. Address reprint requests to: A. Richey Sharrett, MD, DrPH, Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892. Accepted September 4, 1991.
PY - 1992/7
Y1 - 1992/7
N2 - The Atherosclerosis Risk in Communities (ARIC) Study is an observational epidemiologic study conducted in four communities. ARIC has two major components: One records the occurrence of myocardial infarction resulting in hospitalization and coronary heart disease death in adults aged 35 to 74 living in the communities; the other is a prospective study of representative cohorts aged 45 to 64. Measurement of hemostatic factors is part of the cohort study, whose major objectives include investigating etiologic factors associated with atherosclerosis and its clinical outcomes. Arterial intimal-medial wall thickness, an index of early atherosclerosis, is measured precisely from ultrasound images of carotid and popliteal arteries. Participants (n = 15,801) completed their first examination, which included measurements of factors associated with coagulation (fibrinogen, factor VII, factor VIII, and von Willebrand factor) and coagulation inhibition (protein C and antithrombin III). Measures of coagulation activation, platelet activation, and fibrinolytic activity will be performed on stored plasma from selected case patients and control subjects.
AB - The Atherosclerosis Risk in Communities (ARIC) Study is an observational epidemiologic study conducted in four communities. ARIC has two major components: One records the occurrence of myocardial infarction resulting in hospitalization and coronary heart disease death in adults aged 35 to 74 living in the communities; the other is a prospective study of representative cohorts aged 45 to 64. Measurement of hemostatic factors is part of the cohort study, whose major objectives include investigating etiologic factors associated with atherosclerosis and its clinical outcomes. Arterial intimal-medial wall thickness, an index of early atherosclerosis, is measured precisely from ultrasound images of carotid and popliteal arteries. Participants (n = 15,801) completed their first examination, which included measurements of factors associated with coagulation (fibrinogen, factor VII, factor VIII, and von Willebrand factor) and coagulation inhibition (protein C and antithrombin III). Measures of coagulation activation, platelet activation, and fibrinolytic activity will be performed on stored plasma from selected case patients and control subjects.
KW - Cardiovascular disease
KW - hemostasis
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U2 - 10.1016/1047-2797(92)90096-9
DO - 10.1016/1047-2797(92)90096-9
M3 - Article
C2 - 1342297
AN - SCOPUS:0026741830
SN - 1047-2797
VL - 2
SP - 467
EP - 469
JO - Annals of epidemiology
JF - Annals of epidemiology
IS - 4
ER -