The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

Andy Menke, Eliseo Guallar, Meredith S. Shiels, Sabine Rohrmann, Shehzad Basaria, Nader Rifai, William G Nelson, Elizabeth A Platz

Research output: Contribution to journalArticle


Background. Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods. In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results. After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend <0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion. Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.

Original languageEnglish (US)
Article number72
JournalBMC Public Health
StatePublished - 2008


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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