The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

Andy Menke; Eliseo Guallar; Meredith S. Shiels; Sabine Rohrmann; Shehzad Basaria; Nader Rifai; William G. Nelson; Elizabeth A. Platz

doi:10.1186/1471-2458-8-72

The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

Andy Menke, Eliseo Guallar, Meredith S. Shiels, Sabine Rohrmann, Shehzad Basaria, Nader Rifai, William G. Nelson, Elizabeth A. Platz

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background. Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods. In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results. After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend < 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion. Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.

Original language	English (US)
Article number	72
Journal	BMC public health
Volume	8
DOIs	https://doi.org/10.1186/1471-2458-8-72
State	Published - 2008

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1186/1471-2458-8-72

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title = "The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men",

abstract = "Background. Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods. In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results. After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend < 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion. Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.",

author = "Andy Menke and Eliseo Guallar and Shiels, {Meredith S.} and Sabine Rohrmann and Shehzad Basaria and Nader Rifai and Nelson, {William G.} and Platz, {Elizabeth A.}",

note = "Funding Information: The Hormone Demonstration Program was supported by the Maryland Cigarette Restitution Fund Research Grant Program at the Johns Hopkins Medical Institutions.",

year = "2008",

doi = "10.1186/1471-2458-8-72",

language = "English (US)",

volume = "8",

journal = "BMC public health",

issn = "1471-2458",

publisher = "BioMed Central",

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TY - JOUR

T1 - The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

AU - Menke, Andy

AU - Guallar, Eliseo

AU - Shiels, Meredith S.

AU - Rohrmann, Sabine

AU - Basaria, Shehzad

AU - Rifai, Nader

AU - Nelson, William G.

AU - Platz, Elizabeth A.

N1 - Funding Information: The Hormone Demonstration Program was supported by the Maryland Cigarette Restitution Fund Research Grant Program at the Johns Hopkins Medical Institutions.

PY - 2008

Y1 - 2008

N2 - Background. Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods. In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results. After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend < 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion. Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.

AB - Background. Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods. In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results. After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend < 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion. Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.

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The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

Abstract

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