TY - JOUR
T1 - The Association of Race With Frailty
T2 - The Cardiovascular Health Study
AU - Hirsch, Calvin
AU - Anderson, Melissa L.
AU - Newman, Anne
AU - Kop, Willem
AU - Jackson, Sharon
AU - Gottdiener, John
AU - Tracy, Russell
AU - Fried, Linda P.
N1 - Funding Information:
The research reported in this article was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, and N01 HC-15103 from the National Heart, Lung, and Blood Institute.
PY - 2006/7
Y1 - 2006/7
N2 - Purpose: Frailty, which has been conceptualized as a state of decreased physiologic reserve contributing to functional decline, has a prevalence among older African Americans that is twice that in older whites. This study assesses the independent contribution of race to frailty. Methods: We evaluated 786 African-American and 4491 white participants of the Cardiovascular Health Study (CHS). Frailty is defined as meeting three or more of five criteria derived from CHS measures: lowest quintile for grip strength, self-reported exhaustion, unintentional weight loss of 10 lbs or greater in 1 year, slowest quintile for gait speed, and lowest quintile for physical activity. Controlling for age, sex, comorbidity, socioeconomic factors, and race, multinomial logistic regression estimated the odds ratio (OR) of prefrail (one or two criteria) to not frail and frail to not frail. Results: Among African Americans, 8.7% of men and 15.0% of women were frail compared with 4.6% and 6.8% of white men and women, respectively. In adjusted models, nonobese African Americans had a fourfold greater odds of frailty compared with whites. The increased OR of frailty associated with African-American race was less pronounced among those who were obese or disabled. Conclusion: African-American race is associated independently with frailty.
AB - Purpose: Frailty, which has been conceptualized as a state of decreased physiologic reserve contributing to functional decline, has a prevalence among older African Americans that is twice that in older whites. This study assesses the independent contribution of race to frailty. Methods: We evaluated 786 African-American and 4491 white participants of the Cardiovascular Health Study (CHS). Frailty is defined as meeting three or more of five criteria derived from CHS measures: lowest quintile for grip strength, self-reported exhaustion, unintentional weight loss of 10 lbs or greater in 1 year, slowest quintile for gait speed, and lowest quintile for physical activity. Controlling for age, sex, comorbidity, socioeconomic factors, and race, multinomial logistic regression estimated the odds ratio (OR) of prefrail (one or two criteria) to not frail and frail to not frail. Results: Among African Americans, 8.7% of men and 15.0% of women were frail compared with 4.6% and 6.8% of white men and women, respectively. In adjusted models, nonobese African Americans had a fourfold greater odds of frailty compared with whites. The increased OR of frailty associated with African-American race was less pronounced among those who were obese or disabled. Conclusion: African-American race is associated independently with frailty.
KW - Aging
KW - Blacks
KW - Disabled Persons
KW - Frail Elderly
KW - Whites
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U2 - 10.1016/j.annepidem.2005.10.003
DO - 10.1016/j.annepidem.2005.10.003
M3 - Article
C2 - 16388967
AN - SCOPUS:33745457835
SN - 1047-2797
VL - 16
SP - 545
EP - 553
JO - Annals of epidemiology
JF - Annals of epidemiology
IS - 7
ER -