Abstract
Some research and clinical observations have linked Neurofibromatosis Type 1 (NF-1) and Attention Deficit Hyperactivity Disorder (ADHD). In order to investigate whether ADHD is part of the phenotype of NF-1 or is a separate, unrelated disorder within families, we compared the ADHD status of children affected with NF-1 to that of their unaffected-NF-1 siblings and to that of their biological parents. Results of matched-pair analyses were calculated and revealed a significant with-in pair discordance, when comparing children with NF-1 and their siblings and when comparing children with NF-1 and their biological parents (in families with a sporadic, non-familial NF-1 child). These findings suggest that ADHD may occur as a component of the NF-1 phenotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 185-194 |
| Number of pages | 10 |
| Journal | Child Neuropsychology |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
Fingerprint
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Neuropsychology and Physiological Psychology
Cite this
The association of Neurofibromatosis Type 1 and Attention Deficit Hyperactivity Disorder. / Koth, C. W.; Cutting, L. E.; Denckla, Martha Bridge.
In: Child Neuropsychology, Vol. 6, No. 3, 2001, p. 185-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association of Neurofibromatosis Type 1 and Attention Deficit Hyperactivity Disorder
AU - Koth, C. W.
AU - Cutting, L. E.
AU - Denckla, Martha Bridge
PY - 2001
Y1 - 2001
N2 - Some research and clinical observations have linked Neurofibromatosis Type 1 (NF-1) and Attention Deficit Hyperactivity Disorder (ADHD). In order to investigate whether ADHD is part of the phenotype of NF-1 or is a separate, unrelated disorder within families, we compared the ADHD status of children affected with NF-1 to that of their unaffected-NF-1 siblings and to that of their biological parents. Results of matched-pair analyses were calculated and revealed a significant with-in pair discordance, when comparing children with NF-1 and their siblings and when comparing children with NF-1 and their biological parents (in families with a sporadic, non-familial NF-1 child). These findings suggest that ADHD may occur as a component of the NF-1 phenotype.
AB - Some research and clinical observations have linked Neurofibromatosis Type 1 (NF-1) and Attention Deficit Hyperactivity Disorder (ADHD). In order to investigate whether ADHD is part of the phenotype of NF-1 or is a separate, unrelated disorder within families, we compared the ADHD status of children affected with NF-1 to that of their unaffected-NF-1 siblings and to that of their biological parents. Results of matched-pair analyses were calculated and revealed a significant with-in pair discordance, when comparing children with NF-1 and their siblings and when comparing children with NF-1 and their biological parents (in families with a sporadic, non-familial NF-1 child). These findings suggest that ADHD may occur as a component of the NF-1 phenotype.
UR - http://www.scopus.com/inward/record.url?scp=0011146769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0011146769&partnerID=8YFLogxK
U2 - 10.1076/chin.6.3.185.3155
DO - 10.1076/chin.6.3.185.3155
M3 - Article
C2 - 11402396
AN - SCOPUS:0011146769
VL - 6
SP - 185
EP - 194
JO - Child Neuropsychology
JF - Child Neuropsychology
SN - 0929-7049
IS - 3
ER -