The association of Neurofibromatosis Type 1 and Attention Deficit Hyperactivity Disorder

C. W. Koth, L. E. Cutting, M. B. Denckla

Research output: Contribution to journalArticle

Abstract

Some research and clinical observations have linked Neurofibromatosis Type 1 (NF-1) and Attention Deficit Hyperactivity Disorder (ADHD). In order to investigate whether ADHD is part of the phenotype of NF-1 or is a separate, unrelated disorder within families, we compared the ADHD status of children affected with NF-1 to that of their unaffected-NF-1 siblings and to that of their biological parents. Results of matched-pair analyses were calculated and revealed a significant with-in pair discordance, when comparing children with NF-1 and their siblings and when comparing children with NF-1 and their biological parents (in families with a sporadic, non-familial NF-1 child). These findings suggest that ADHD may occur as a component of the NF-1 phenotype.

Original languageEnglish (US)
Pages (from-to)185-194
Number of pages10
JournalChild Neuropsychology
Volume6
Issue number3
DOIs
StatePublished - Jul 5 2001

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology

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