@article{63e30f4807444eb28b6288429468ce1c,
title = "The association of life{\textquoteright}s simple 7 with aldosterone among African Americans in the Jackson heart study",
abstract = "Background: Among African Americans (AAs), attaining higher levels of American Heart Association (AHA) ideal cardiovascular health (Life{\textquoteright}s Simple 7 [LS7]) is associated with lower risk of diabetes and cardiovascular disease (CVD). We previously showed that aldosterone is associated with higher risk of diabetes and CVD in AAs. Thus, we investigated the association of LS7 metrics with aldosterone in the Jackson Heart Study (JHS). Methods: Ideal metrics were defined by AHA 2020 goals for health behaviors (smoking, dietary intake, physical activity, and body mass index) and health factors (total cholesterol, blood pressure, and fasting glucose). The number of ideal LS7 metrics attained at baseline were summed into a continuous score (0–7) and categorical groups (Poor: 0–1, Intermediate: 2–3, and Ideal: ≥4 ideal LS7 metrics). Multivariable linear regression was used. Results: Among 4,095 JHS participants (mean age 55 ± 13 years, 65% female), median serum aldosterone was 4.90, 4.30, and 3.70 ng/dL in the poor (n = 1132), intermediate (n = 2288) and ideal (n = 675) categories respectively. Aldosterone was 15% [0.85 (0.80, 0.90)] and 33% [0.67 (0.61, 0.75)] lower in the intermediate and ideal LS7 categories compared to the poor LS7 category. Each additional LS7 metric attained on continuous LS7 score (0–7) was associated with an 11% [0.89 (0.86, 0.91)] lower aldosterone level with variation by sex with women having a 15% lower aldosterone vs. 5% in men. Conclusions: Higher attainment of ideal LS7 metrics was associated with lower serum aldosterone among AAs with a greater magnitude of association among women compared to men.",
keywords = "African Americans, Aldosterone, Blood pressure, Body mass index, Cholesterol, Glucose, Ideal cardiovascular health, Life{\textquoteright}s Simple 7, Physical activity, Smoking",
author = "Veena Kesireddy and Yubo Tan and David Kline and Guy Brock and Odei, {James B.} and Bjorn Kluwe and Effoe, {Valery S.} and Tcheugui, {Justin B.Echouffo} and Kalyani, {Rita R.} and Mario Sims and Taylor, {Herman A.} and Morgana Mongraw-Chaffin and Ehimare Akhabue and Joseph, {Joshua J.}",
note = "Funding Information: Funding: The JHS Diabetes and Obesity Working Group is supported by R01 HL117285-01 from the National Heart, Lung, and Blood Institute. The Jackson Heart Study is supported by contracts HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, and HHSN268201300050C from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities. J.J.J. was supported by K23 DK117041 from the National Institute of Diabetes and Digestive and Kidney Diseases (USA). The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services. Funding Information: Acknowledgments: The authors thank the other investigators, the staff, and the participants of the Jackson Heart Study for their valuable contributions. There are no relevant financial interests, activities, relationships, or affiliations to disclose on the part of any author. Veena Kesireddy, MD was supported by The Division of Endocrinology, Diabetes and Metabolism at The Ohio State University Wexner Medical Center. Funding Information: The JHS Diabetes and Obesity Working Group is supported by R01 HL117285-01 from the National Heart, Lung, and Blood Institute. The Jackson Heart Study is supported by contracts HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, and HHSN268201300050C from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities. J.J.J. was supported by K23 DK117041 from the National Institute of Diabetes and Digestive and Kidney Diseases (USA). The views expressed in this article are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the US Department of Health and Human Services. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = may,
doi = "10.3390/nu11050955",
language = "English (US)",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",
}