The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

Jessica L. Elf, Aarti Kinikar, Sandhya Khadse, Vidya Mave, Nishi Suryavanshi, Nikhil Gupte, Vaishali Kulkarni, Sunita Patekar, Priyanka Raichur, Mandar Paradkar, Vandana Kulkarni, Neeta Pradhan, Patrick N. Breysse, Amita Gupta, Jonathan E. Golub

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Household air pollution (HAP) is a risk factor for respiratory disease, however has yet to be definitively associated with tuberculosis (TB). We aimed to assess the association between HAP and TB. Methods: A matched case-control study was conducted among adult women and children patients with TB and healthy controls matched on geography, age and sex. HAP was assessed using questionnaires for pollution sources and 24-hour household concentrations of particulate matter <2.5 μm in diameter (PM2.5). Results: In total, 192 individuals in 96 matched pairs were included. The median 24-hour time-weighted average PM2.5 was nearly seven times higher than the WHO's recommendation of 25 μg/m3, and did not vary between controls (179 μg/m3; IQR: 113-292) and cases (median 157 μg/m3; 95% CI 93 to 279; p=0.57). Reported use of wood fuel was not associated with TB (OR 2.32; 95% CI 0.65 to 24.20) and kerosene was significantly associated with TB (OR 5.49, 95% CI 1.24 to 24.20) in adjusted analysis. Household PM2.5 was not associated with TB in univariate or adjusted analysis. Controlling for PM2.5 concentration, kerosene was not significantly associated with TB, but effect sizes ranged from OR 4.30 (95% CI 0.78 to 30.86; p=0.09) to OR 5.49 (0.82 to 36.75; p=0.08). Conclusions: Use of kerosene cooking fuel is positively associated with TB in analysis using reported sources of exposure. Ubiquitously high levels of particulates limited detection of a difference in household PM2.5 between cases and controls.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalOccupational and Environmental Medicine
Volume76
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • air pollution
  • cooking fuel
  • pm2.5
  • social determinants

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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