The association of herpes simplex virus type 2 (HSV-2), Haemophilus ducreyi, and syphilis with HIV infection in young men in northern Thailand

Kenrad E. Nelson, Sakol Eiumtrakul, David Celentano, Ian Maclean, Allan Ronald, Somboon Suprasert, Donald R. Hoover, Surinda Kuntolbutra, Jonathan M. Zenilman

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the association between sexually transmitted diseases that commonly may cause genital ulceration and prevalent and incident HIV infections, we conducted three case control studies in a cohort of 21-year- old male military conscripts in northern Thailand. The men were evaluated at baseline in 1991 and semiannually until their discharge 2 years later. Serologic evidence of infection with herpes simplex virus type 2 (HSV-2), Haemophilus ducreyi, and HIV were more frequent at baseline in 83 men with a history of genital ulcer than in 97 men without such a history. Seropositivity to H. ducreyi (odds ratio [OR] = 3.46), HSV-2 (OR = 3.83), and syphilis (OR = 1.53) were more common in HIV-positive than HIV-negative men. Men (N = 45) who seroconverted to HIV while in the military were more often seropositive for H. ducreyi and HSV-2 before HIV seroconversion and also were more likely to seroconvert to HSV-2 and H. ducreyi during the same interval as their HIV seroconversion compared with men who remained HIV-negative. These data suggest that HSV-2 and H. ducreyi may be both markers for high- risk sexual behavior and risk factors for HIV infection among young men in Thailand.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume16
Issue number4
DOIs
StatePublished - Dec 1 1997

Keywords

  • HIV
  • Haemophilus ducreyi
  • Herpes simplex type 2
  • Syphilis
  • Thailand

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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