The association of herpes simplex virus type 2 (HSV-2), Haemophilus ducreyi, and syphilis with HIV infection in young men in northern Thailand

Kenrad Edwin Nelson, Sakol Eiumtrakul, David D Celentano, Ian Maclean, Allan Ronald, Somboon Suprasert, Donald R. Hoover, Surinda Kuntolbutra, Jonathan Mark Zenilman

Research output: Contribution to journalArticle


To evaluate the association between sexually transmitted diseases that commonly may cause genital ulceration and prevalent and incident HIV infections, we conducted three case control studies in a cohort of 21-year- old male military conscripts in northern Thailand. The men were evaluated at baseline in 1991 and semiannually until their discharge 2 years later. Serologic evidence of infection with herpes simplex virus type 2 (HSV-2), Haemophilus ducreyi, and HIV were more frequent at baseline in 83 men with a history of genital ulcer than in 97 men without such a history. Seropositivity to H. ducreyi (odds ratio [OR] = 3.46), HSV-2 (OR = 3.83), and syphilis (OR = 1.53) were more common in HIV-positive than HIV-negative men. Men (N = 45) who seroconverted to HIV while in the military were more often seropositive for H. ducreyi and HSV-2 before HIV seroconversion and also were more likely to seroconvert to HSV-2 and H. ducreyi during the same interval as their HIV seroconversion compared with men who remained HIV-negative. These data suggest that HSV-2 and H. ducreyi may be both markers for high- risk sexual behavior and risk factors for HIV infection among young men in Thailand.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Issue number4
Publication statusPublished - Dec 1 1997



  • Haemophilus ducreyi
  • Herpes simplex type 2
  • HIV
  • Syphilis
  • Thailand

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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