The association of hepatitis delta virus and hepatitis B virus in parenteral drug abusers 1971 to 1972 and 1986 to 1987

W. Robert Lange, Edward J. Cone, Frederick R. Snyder

Research output: Contribution to journalArticle

Abstract

From 1971 to 1972 (N = 105) and 1986 to 1987 (N = 160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting antl-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was wide-spread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalArchives of Internal Medicine
Volume150
Issue number2
StatePublished - Feb 1990

Fingerprint

Hepatitis D
Hepatitis Delta Virus
Hepatitis B Surface Antigens
Drug Users
Hepatitis B virus
Hepatitis B Antibodies
Geographic Locations
Antibodies

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The association of hepatitis delta virus and hepatitis B virus in parenteral drug abusers 1971 to 1972 and 1986 to 1987. / Lange, W. Robert; Cone, Edward J.; Snyder, Frederick R.

In: Archives of Internal Medicine, Vol. 150, No. 2, 02.1990, p. 365-368.

Research output: Contribution to journalArticle

Lange, W. Robert ; Cone, Edward J. ; Snyder, Frederick R. / The association of hepatitis delta virus and hepatitis B virus in parenteral drug abusers 1971 to 1972 and 1986 to 1987. In: Archives of Internal Medicine. 1990 ; Vol. 150, No. 2. pp. 365-368.
@article{6a4143f8eb874bf2b0b1572d89cd0e08,
title = "The association of hepatitis delta virus and hepatitis B virus in parenteral drug abusers 1971 to 1972 and 1986 to 1987",
abstract = "From 1971 to 1972 (N = 105) and 1986 to 1987 (N = 160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31{\%} of those positive for hepatitis B surface antigen from the early sample and 20{\%} of those from the latter sample had detectable anti-HD, as opposed to 10{\%} and 7{\%}, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting antl-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was wide-spread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies.",
author = "Lange, {W. Robert} and Cone, {Edward J.} and Snyder, {Frederick R.}",
year = "1990",
month = "2",
language = "English (US)",
volume = "150",
pages = "365--368",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - The association of hepatitis delta virus and hepatitis B virus in parenteral drug abusers 1971 to 1972 and 1986 to 1987

AU - Lange, W. Robert

AU - Cone, Edward J.

AU - Snyder, Frederick R.

PY - 1990/2

Y1 - 1990/2

N2 - From 1971 to 1972 (N = 105) and 1986 to 1987 (N = 160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting antl-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was wide-spread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies.

AB - From 1971 to 1972 (N = 105) and 1986 to 1987 (N = 160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting antl-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was wide-spread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies.

UR - http://www.scopus.com/inward/record.url?scp=0025013026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025013026&partnerID=8YFLogxK

M3 - Article

C2 - 2302011

AN - SCOPUS:0025013026

VL - 150

SP - 365

EP - 368

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 2

ER -