The association of e-cigarette use with exposure to nickel and chromium: A preliminary study of non-invasive biomarkers

Angela Aherrera, Pablo Olmedo, Maria Grau-Perez, Stefan Tanda, Walter Goessler, Stephanie Jarmul, Rui Chen, Joanna E Cohen, Ana M Rule, Ana Navas Acien

Research output: Contribution to journalArticle

Abstract

Background Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland. Methods We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid). Results Median Ni and Cr levels were 0.73 and 0.39 μg/g creatinine in urine, 2.25 and 1.53 μg/L in saliva, and 1.25 and 0.29 μg/L in EBC. In adjusted models, tertiles 2 and 3 of aerosol Ni concentrations were associated with 16% and 72% higher urine Ni and 202% and 321% higher saliva Ni compared to the lowest tertile. Tertile 3 of aerosol Cr levels were associated with 193% higher saliva Cr. An earlier time to first vape in the morning and more frequent coil change were associated with higher urine Ni. Tertile 2 of e-liquid consumption per week and voltage were associated with higher saliva Ni levels than tertile 1. Conclusion Positive associations of Ni and Cr aerosol concentrations with corresponding Ni and Cr biomarker levels indicate e-cigarette emissions increase metal internal dose. Increased e-cigarette use and consumption were also associated with higher Ni biomarker levels. Metal level standards are needed to prevent involuntary metal exposure among e-cigarette users.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalEnvironmental Research
Volume159
DOIs
StatePublished - Nov 1 2017

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Biomarkers
Chromium
Nickel
Tobacco Products
chromium
biomarker
nickel
Association reactions
saliva
Aerosols
Saliva
Metals
urine
aerosol
Urine
metal
liquid
Liquids
condensate
exposure

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Aherrera, A., Olmedo, P., Grau-Perez, M., Tanda, S., Goessler, W., Jarmul, S., ... Navas Acien, A. (2017). The association of e-cigarette use with exposure to nickel and chromium: A preliminary study of non-invasive biomarkers. Environmental Research, 159, 313-320. https://doi.org/10.1016/j.envres.2017.08.014

The association of e-cigarette use with exposure to nickel and chromium : A preliminary study of non-invasive biomarkers. / Aherrera, Angela; Olmedo, Pablo; Grau-Perez, Maria; Tanda, Stefan; Goessler, Walter; Jarmul, Stephanie; Chen, Rui; Cohen, Joanna E; Rule, Ana M; Navas Acien, Ana.

In: Environmental Research, Vol. 159, 01.11.2017, p. 313-320.

Research output: Contribution to journalArticle

Aherrera, Angela ; Olmedo, Pablo ; Grau-Perez, Maria ; Tanda, Stefan ; Goessler, Walter ; Jarmul, Stephanie ; Chen, Rui ; Cohen, Joanna E ; Rule, Ana M ; Navas Acien, Ana. / The association of e-cigarette use with exposure to nickel and chromium : A preliminary study of non-invasive biomarkers. In: Environmental Research. 2017 ; Vol. 159. pp. 313-320.
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abstract = "Background Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland. Methods We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid). Results Median Ni and Cr levels were 0.73 and 0.39 μg/g creatinine in urine, 2.25 and 1.53 μg/L in saliva, and 1.25 and 0.29 μg/L in EBC. In adjusted models, tertiles 2 and 3 of aerosol Ni concentrations were associated with 16{\%} and 72{\%} higher urine Ni and 202{\%} and 321{\%} higher saliva Ni compared to the lowest tertile. Tertile 3 of aerosol Cr levels were associated with 193{\%} higher saliva Cr. An earlier time to first vape in the morning and more frequent coil change were associated with higher urine Ni. Tertile 2 of e-liquid consumption per week and voltage were associated with higher saliva Ni levels than tertile 1. Conclusion Positive associations of Ni and Cr aerosol concentrations with corresponding Ni and Cr biomarker levels indicate e-cigarette emissions increase metal internal dose. Increased e-cigarette use and consumption were also associated with higher Ni biomarker levels. Metal level standards are needed to prevent involuntary metal exposure among e-cigarette users.",
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AU - Tanda, Stefan

AU - Goessler, Walter

AU - Jarmul, Stephanie

AU - Chen, Rui

AU - Cohen, Joanna E

AU - Rule, Ana M

AU - Navas Acien, Ana

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N2 - Background Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland. Methods We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid). Results Median Ni and Cr levels were 0.73 and 0.39 μg/g creatinine in urine, 2.25 and 1.53 μg/L in saliva, and 1.25 and 0.29 μg/L in EBC. In adjusted models, tertiles 2 and 3 of aerosol Ni concentrations were associated with 16% and 72% higher urine Ni and 202% and 321% higher saliva Ni compared to the lowest tertile. Tertile 3 of aerosol Cr levels were associated with 193% higher saliva Cr. An earlier time to first vape in the morning and more frequent coil change were associated with higher urine Ni. Tertile 2 of e-liquid consumption per week and voltage were associated with higher saliva Ni levels than tertile 1. Conclusion Positive associations of Ni and Cr aerosol concentrations with corresponding Ni and Cr biomarker levels indicate e-cigarette emissions increase metal internal dose. Increased e-cigarette use and consumption were also associated with higher Ni biomarker levels. Metal level standards are needed to prevent involuntary metal exposure among e-cigarette users.

AB - Background Nickel (Ni) and chromium (Cr) are components of e-cigarette heating coils. Whether e-cigarettes increase metal internal dose, however, is unknown. We assessed the association of e-cigarette use patterns and of e-liquid and aerosol metal concentrations with Ni and Cr biomarker levels in e-cigarette users from Maryland. Methods We recruited 64 e-cigarette users from December 2015 to March 2016. We collected urine, saliva, and exhaled breath condensate (EBC), data on e-cigarette use, and samples from their e-cigarette device (dispenser e-liquid, aerosol, and tank e-liquid). Results Median Ni and Cr levels were 0.73 and 0.39 μg/g creatinine in urine, 2.25 and 1.53 μg/L in saliva, and 1.25 and 0.29 μg/L in EBC. In adjusted models, tertiles 2 and 3 of aerosol Ni concentrations were associated with 16% and 72% higher urine Ni and 202% and 321% higher saliva Ni compared to the lowest tertile. Tertile 3 of aerosol Cr levels were associated with 193% higher saliva Cr. An earlier time to first vape in the morning and more frequent coil change were associated with higher urine Ni. Tertile 2 of e-liquid consumption per week and voltage were associated with higher saliva Ni levels than tertile 1. Conclusion Positive associations of Ni and Cr aerosol concentrations with corresponding Ni and Cr biomarker levels indicate e-cigarette emissions increase metal internal dose. Increased e-cigarette use and consumption were also associated with higher Ni biomarker levels. Metal level standards are needed to prevent involuntary metal exposure among e-cigarette users.

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