The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults

Evadnie Rampersaud; Lawrence F. Bielak; Afshin Parsa; Haiqing Shen; Wendy Post; Kathleen A. Ryan; Patrick Donnelly; John A. Rumberger; Patrick F. Sheedy; Patricia A. Peyser; Alan R. Shuldiner; Braxton D. Mitchell

doi:10.1093/aje/kwn211

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults

Evadnie Rampersaud, Lawrence F. Bielak, Afshin Parsa, Haiqing Shen, Wendy Post, Kathleen A. Ryan, Patrick Donnelly, John A. Rumberger, Patrick F. Sheedy, Patricia A. Peyser, Alan R. Shuldiner, Braxton D. Mitchell

School of Medicine

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Coronary artery calcification (CAC) and common carotid artery intima-media thickness (CIMT) are measures of subclinical vascular disease. This 2000-2006 study aimed to characterize the associations among coronary artery disease risk factors, CAC quantity, and CIMT and to estimate shared genetic and environmental contributions to both CAC and CIMT among 478 asymptomatic Amish adults in Lancaster County, Pennsylvania. Heritability for CAC quantity and CIMT, adjusted for age and sex, was 0.42 (P = 0.0001) and 0.29 (P = 0.003), respectively. CAC quantity and CIMT were modestly correlated (adjusted r = 0.14, P = 0.003) but showed little evidence of shared genetic or environmental factors. However, significant genetic correlations were found for CAC quantity and total cholesterol (0.44 (standard error, 0.19); P = 0.03), for CAC quantity and low density lipoprotein cholesterol (0.55 (standard error, 0.17); P = 0.005), and for CIMT and waist circumference (0.58 (standard error, 0.25); P = 0.046), suggesting shared genes for these risk factors and measures of subclinical disease. Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference.

Original language	English (US)
Pages (from-to)	1016-1023
Number of pages	8
Journal	American journal of epidemiology
Volume	168
Issue number	9
DOIs	https://doi.org/10.1093/aje/kwn211
State	Published - Nov 2008

Keywords

Atherosclerosis
Calcification, physiologic
Carotid arteries
Coronary vessels
Genetics
Risk factors
Vascular diseases

ASJC Scopus subject areas

General Medicine

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10.1093/aje/kwn211

Cite this

Rampersaud, E., Bielak, L. F., Parsa, A., Shen, H., Post, W., Ryan, K. A., Donnelly, P., Rumberger, J. A., Sheedy, P. F., Peyser, P. A., Shuldiner, A. R., & Mitchell, B. D. (2008). The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults. American journal of epidemiology, 168(9), 1016-1023. https://doi.org/10.1093/aje/kwn211

The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults. / Rampersaud, Evadnie; Bielak, Lawrence F.; Parsa, Afshin et al.
In: American journal of epidemiology, Vol. 168, No. 9, 11.2008, p. 1016-1023.

Research output: Contribution to journal › Article › peer-review

Rampersaud, E, Bielak, LF, Parsa, A, Shen, H, Post, W, Ryan, KA, Donnelly, P, Rumberger, JA, Sheedy, PF, Peyser, PA, Shuldiner, AR & Mitchell, BD 2008, 'The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults', American journal of epidemiology, vol. 168, no. 9, pp. 1016-1023. https://doi.org/10.1093/aje/kwn211

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abstract = "Coronary artery calcification (CAC) and common carotid artery intima-media thickness (CIMT) are measures of subclinical vascular disease. This 2000-2006 study aimed to characterize the associations among coronary artery disease risk factors, CAC quantity, and CIMT and to estimate shared genetic and environmental contributions to both CAC and CIMT among 478 asymptomatic Amish adults in Lancaster County, Pennsylvania. Heritability for CAC quantity and CIMT, adjusted for age and sex, was 0.42 (P = 0.0001) and 0.29 (P = 0.003), respectively. CAC quantity and CIMT were modestly correlated (adjusted r = 0.14, P = 0.003) but showed little evidence of shared genetic or environmental factors. However, significant genetic correlations were found for CAC quantity and total cholesterol (0.44 (standard error, 0.19); P = 0.03), for CAC quantity and low density lipoprotein cholesterol (0.55 (standard error, 0.17); P = 0.005), and for CIMT and waist circumference (0.58 (standard error, 0.25); P = 0.046), suggesting shared genes for these risk factors and measures of subclinical disease. Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference.",

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AU - Post, Wendy

AU - Ryan, Kathleen A.

AU - Donnelly, Patrick

AU - Rumberger, John A.

AU - Sheedy, Patrick F.

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AU - Shuldiner, Alan R.

AU - Mitchell, Braxton D.

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AB - Coronary artery calcification (CAC) and common carotid artery intima-media thickness (CIMT) are measures of subclinical vascular disease. This 2000-2006 study aimed to characterize the associations among coronary artery disease risk factors, CAC quantity, and CIMT and to estimate shared genetic and environmental contributions to both CAC and CIMT among 478 asymptomatic Amish adults in Lancaster County, Pennsylvania. Heritability for CAC quantity and CIMT, adjusted for age and sex, was 0.42 (P = 0.0001) and 0.29 (P = 0.003), respectively. CAC quantity and CIMT were modestly correlated (adjusted r = 0.14, P = 0.003) but showed little evidence of shared genetic or environmental factors. However, significant genetic correlations were found for CAC quantity and total cholesterol (0.44 (standard error, 0.19); P = 0.03), for CAC quantity and low density lipoprotein cholesterol (0.55 (standard error, 0.17); P = 0.005), and for CIMT and waist circumference (0.58 (standard error, 0.25); P = 0.046), suggesting shared genes for these risk factors and measures of subclinical disease. Results suggest that some of the same genes influence variation in CAC and low density lipoprotein cholesterol, whereas a different set of genes influences variation in CIMT and waist circumference.

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The association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adults

Abstract

Keywords

ASJC Scopus subject areas

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