Abstract
Background and aims Many US adults use calcium supplements to address inadequate dietary intake and improve bone health. However, recent reports have suggested that use of calcium supplements may elevate cardiovascular disease (CVD) risk. In this study, we examined associations between baseline calcium supplement use and incident myocardial infarction (MI) (n = 208 events) and CVD events (n = 641 events) over 10.3 years in men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (n = 6236), with dietary calcium intake at baseline also examined as a supplementary objective. Methods and results Using Cox proportional hazards models, no compelling associations between calcium intake from supplements or diet and incident CVD events were observed upon multivariate adjustment for potential confounders. An association with lower MI risk was observed comparing those with low levels of calcium supplement use (1–499 mg) to those using no calcium supplements (hazard ratio 0.69, 95% CI 0.48, 0.98, p = 0.039). Relationships were homogeneous by gender, race/ethnicity, or chronic kidney disease. Results were also similar when the analysis was limited to postmenopausal women only. Conclusion Analysis of incident MI and CVD events in the MESA cohort does not support a substantial association of calcium supplement use with negative cardiovascular outcomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 899-907 |
| Number of pages | 9 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 26 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2016 |
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Keywords
- Calcium
- Cardiovascular disease
- Multi-ethnic Study of Atherosclerosis
- Myocardial infarction
- Supplements
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
Cite this
The association of calcium supplementation and incident cardiovascular events in the Multi-ethnic Study of Atherosclerosis (MESA). / Raffield, L. M.; Agarwal, S.; Hsu, F. C.; de Boer, I. H.; Ix, J. H.; Siscovick, D.; Szklo, Moyses; Burke, G. L.; Frazier-Wood, A. C.; Herrington, D. M.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 26, No. 10, 01.10.2016, p. 899-907.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association of calcium supplementation and incident cardiovascular events in the Multi-ethnic Study of Atherosclerosis (MESA)
AU - Raffield, L. M.
AU - Agarwal, S.
AU - Hsu, F. C.
AU - de Boer, I. H.
AU - Ix, J. H.
AU - Siscovick, D.
AU - Szklo, Moyses
AU - Burke, G. L.
AU - Frazier-Wood, A. C.
AU - Herrington, D. M.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background and aims Many US adults use calcium supplements to address inadequate dietary intake and improve bone health. However, recent reports have suggested that use of calcium supplements may elevate cardiovascular disease (CVD) risk. In this study, we examined associations between baseline calcium supplement use and incident myocardial infarction (MI) (n = 208 events) and CVD events (n = 641 events) over 10.3 years in men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (n = 6236), with dietary calcium intake at baseline also examined as a supplementary objective. Methods and results Using Cox proportional hazards models, no compelling associations between calcium intake from supplements or diet and incident CVD events were observed upon multivariate adjustment for potential confounders. An association with lower MI risk was observed comparing those with low levels of calcium supplement use (1–499 mg) to those using no calcium supplements (hazard ratio 0.69, 95% CI 0.48, 0.98, p = 0.039). Relationships were homogeneous by gender, race/ethnicity, or chronic kidney disease. Results were also similar when the analysis was limited to postmenopausal women only. Conclusion Analysis of incident MI and CVD events in the MESA cohort does not support a substantial association of calcium supplement use with negative cardiovascular outcomes.
AB - Background and aims Many US adults use calcium supplements to address inadequate dietary intake and improve bone health. However, recent reports have suggested that use of calcium supplements may elevate cardiovascular disease (CVD) risk. In this study, we examined associations between baseline calcium supplement use and incident myocardial infarction (MI) (n = 208 events) and CVD events (n = 641 events) over 10.3 years in men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (n = 6236), with dietary calcium intake at baseline also examined as a supplementary objective. Methods and results Using Cox proportional hazards models, no compelling associations between calcium intake from supplements or diet and incident CVD events were observed upon multivariate adjustment for potential confounders. An association with lower MI risk was observed comparing those with low levels of calcium supplement use (1–499 mg) to those using no calcium supplements (hazard ratio 0.69, 95% CI 0.48, 0.98, p = 0.039). Relationships were homogeneous by gender, race/ethnicity, or chronic kidney disease. Results were also similar when the analysis was limited to postmenopausal women only. Conclusion Analysis of incident MI and CVD events in the MESA cohort does not support a substantial association of calcium supplement use with negative cardiovascular outcomes.
KW - Calcium
KW - Cardiovascular disease
KW - Multi-ethnic Study of Atherosclerosis
KW - Myocardial infarction
KW - Supplements
UR - http://www.scopus.com/inward/record.url?scp=84995488471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995488471&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2016.07.007
DO - 10.1016/j.numecd.2016.07.007
M3 - Article
VL - 26
SP - 899
EP - 907
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 10
ER -