The association of arterial shear and flow-mediated dilation in diabetes

Bethany Barone Gibbs, Devon A. Dobrosielski, Michael Lima, Susanne Bonekamp, Kerry J. Stewart, Jeanne M. Clark

Research output: Contribution to journalArticlepeer-review

Abstract

While adjusting flow-mediated dilation (FMD), a measure of vascular function, for shear rate may be important when evaluating endothelial-dependent vasodilation, the relationship of FMD with shear rate in study populations with cardiovascular risk factors is unclear. We aimed to investigate the association of four measures of shear rate (peak shear rate (SR peak) and shear rate area under the curve through 30 seconds (SR AUC 0-30), 60 seconds (SR AUC 0-60), and time to peak dilation (SR AUC 0-ttp)) with FMD in 50 study subjects with type 2 diabetes and mild hypertension undergoing baseline FMD testing for an exercise intervention trial. Associations among measures of shear rate and FMD were evaluated using Pearson's correlations and R 2. The four measures of shear rate were highly correlated within subjects, with Pearson's correlations ranging from 0.783 (p < 0.001) to 0.972 (p < 0.001). FMD was associated with each measure of shear rate, having a correlation of 0.576 (p < 0.001) with SR AUC 0-30, 0.529 (p < 0.001) with SRAUC 0-60, and 0.512 (p < 0.001) with SRpeak. Nine of 50 subjects (18%) did not dilate following the shear stimulus. Among the 41 responders, FMD had a correlation of 0.517 (p < 0.001) with SR AUC 0-ttp and similar correlations to those found in the full sample for SR AUC 0-30, SR AUC 0-60, and SRpeak. In conclusion, shear rate appears to explain up to a third of between-person variability in FMD response and our results support the reporting of shear rate and FMD with and without adjustment for shear rate in similar clinical populations with CVD risk factors.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalVascular Medicine
Volume16
Issue number4
DOIs
StatePublished - Aug 2011

Keywords

  • diabetes
  • endothelial function
  • shear rate
  • vascular responsiveness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'The association of arterial shear and flow-mediated dilation in diabetes'. Together they form a unique fingerprint.

Cite this