The Association of Alcohol Consumption and Incident Heart Failure. The Cardiovascular Health Study

Chris L. Bryson, Kenneth J. Mukamal, Murray A. Mittleman, Linda P Fried, Calvin H. Hirsch, Dalane W. Kitzman, David S. Siscovick

Research output: Contribution to journalArticle

Abstract

Objectives: We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI). Background: Moderate alcohol consumption has been associated with lower risk of CHF and MI. Methods: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption. Results: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week (hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.67 to 1.00, p = 0.05) and 7 to 13 drinks per week (HR 0.66, 95% CI 0.47 to 0.91, p = 0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF (for 1 to 6 drinks per week, HR 0.84, 95% CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95% CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers (HR 1.51, p <0.01), but those who quit during the study did not have a higher risk (HR 0.83, 95% CI 0.66 to 1.03). Conclusions: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalJournal of the American College of Cardiology
Volume48
Issue number2
DOIs
StatePublished - Jul 18 2006

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Alcohol Drinking
Heart Failure
Health
Confidence Intervals
Myocardial Infarction
Alcohols
Proportional Hazards Models
Cohort Studies
Cardiovascular Diseases
Odds Ratio
Prospective Studies

ASJC Scopus subject areas

  • Nursing(all)

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The Association of Alcohol Consumption and Incident Heart Failure. The Cardiovascular Health Study. / Bryson, Chris L.; Mukamal, Kenneth J.; Mittleman, Murray A.; Fried, Linda P; Hirsch, Calvin H.; Kitzman, Dalane W.; Siscovick, David S.

In: Journal of the American College of Cardiology, Vol. 48, No. 2, 18.07.2006, p. 305-311.

Research output: Contribution to journalArticle

Bryson, Chris L. ; Mukamal, Kenneth J. ; Mittleman, Murray A. ; Fried, Linda P ; Hirsch, Calvin H. ; Kitzman, Dalane W. ; Siscovick, David S. / The Association of Alcohol Consumption and Incident Heart Failure. The Cardiovascular Health Study. In: Journal of the American College of Cardiology. 2006 ; Vol. 48, No. 2. pp. 305-311.
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abstract = "Objectives: We investigated the association between alcohol consumption and incident congestive heart failure (CHF) both overall and after adjusting for incident myocardial infarction (MI). Background: Moderate alcohol consumption has been associated with lower risk of CHF and MI. Methods: The Cardiovascular Health study, a prospective cohort study of cardiovascular disease risk factors and outcomes, followed 5,888 subjects ≥65 years old for 7 to 10 years. Cox models were used to estimate the adjusted risk of CHF by reported alcohol consumption. Results: There were 5,595 subjects at baseline at risk for incident CHF with alcohol data and 1,056 events during follow-up. Compared with abstainers, the adjusted risk of CHF was lower among subjects who reported consuming 1 to 6 drinks per week (hazard ratio [HR] 0.82, 95{\%} confidence interval [CI] 0.67 to 1.00, p = 0.05) and 7 to 13 drinks per week (HR 0.66, 95{\%} CI 0.47 to 0.91, p = 0.01). Time-dependent adjustment for incident MI altered only slightly the association between moderate alcohol consumption and CHF (for 1 to 6 drinks per week, HR 0.84, 95{\%} CI 0.65 to 1.04; for 7 to 13 drinks per week, HR 0.69, 95{\%} CI 0.49 to 0.99). Baseline former drinkers had a higher risk of CHF than abstainers (HR 1.51, p <0.01), but those who quit during the study did not have a higher risk (HR 0.83, 95{\%} CI 0.66 to 1.03). Conclusions: Moderate alcohol use is associated with a lower risk of incident CHF among older adults, even after accounting for incident MI and other factors.",
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