TY - JOUR
T1 - The Association of Adverse Pregnancy Outcomes and Cardiovascular Disease
T2 - Current Knowledge and Future Directions
AU - Minhas, Anum S.
AU - Ying, Wendy
AU - Ogunwole, S. Michelle
AU - Miller, Michael
AU - Zakaria, Sammy
AU - Vaught, Arthur J.
AU - Hays, Allison G.
AU - Creanga, Andreea A.
AU - Cedars, Ari
AU - Michos, Erin D.
AU - Blumenthal, Roger S.
AU - Sharma, Garima
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Purpose of review: Adverse pregnancy outcomes are associated with increased risk for future cardiovascular disease. The goal of this review is to share what is currently known about the increased risk and to identify areas for future research. Recent findings: Severe studies have identified a strong association between adverse pregnancy outcomes and cardiovascular disease such as heart failure, valvular disease, ischemic heart disease, stroke, hypertension, and metabolic syndrome. The recognition of this increased risk is reflected in recent changes in prevention guidelines. The guidelines now recognize sex-specific risks such as preeclampsia and preterm delivery and recommend incorporating a pregnancy history to identify them earlier. However, no robust risk prediction tools incorporating these pregnancy risk factors have been developed and validated. While smaller clinical trials have been performed in reducing cardiovascular risk factors in the postpartum timeframe, there remains a paucity of large-scale randomized clinical trials that continue to show a risk reduction in these women. Summary: While there is increasing recognition of the long-term cardiovascular risks associated with adverse pregnancy outcomes, there remains a need for interventional studies aimed at reducing this risk and for incorporation of pregnancy risk factors into traditional cardiovascular risk prediction tools.
AB - Purpose of review: Adverse pregnancy outcomes are associated with increased risk for future cardiovascular disease. The goal of this review is to share what is currently known about the increased risk and to identify areas for future research. Recent findings: Severe studies have identified a strong association between adverse pregnancy outcomes and cardiovascular disease such as heart failure, valvular disease, ischemic heart disease, stroke, hypertension, and metabolic syndrome. The recognition of this increased risk is reflected in recent changes in prevention guidelines. The guidelines now recognize sex-specific risks such as preeclampsia and preterm delivery and recommend incorporating a pregnancy history to identify them earlier. However, no robust risk prediction tools incorporating these pregnancy risk factors have been developed and validated. While smaller clinical trials have been performed in reducing cardiovascular risk factors in the postpartum timeframe, there remains a paucity of large-scale randomized clinical trials that continue to show a risk reduction in these women. Summary: While there is increasing recognition of the long-term cardiovascular risks associated with adverse pregnancy outcomes, there remains a need for interventional studies aimed at reducing this risk and for incorporation of pregnancy risk factors into traditional cardiovascular risk prediction tools.
KW - Adverse pregnancy outcomes
KW - Aspirin
KW - Gestational diabetes
KW - Maternal cardiovascular disease
KW - Preeclampsia
KW - Preterm delivery
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U2 - 10.1007/s11936-020-00862-6
DO - 10.1007/s11936-020-00862-6
M3 - Review article
AN - SCOPUS:85094662213
SN - 1092-8464
VL - 22
JO - Current Treatment Options in Cardiovascular Medicine
JF - Current Treatment Options in Cardiovascular Medicine
IS - 12
M1 - 61
ER -