The association between treatment-related lymphopenia and survival in newly diagnosed patients with resected adenocarcinoma of the pancreas

Ani Balmanoukian, Xiaobu Ye, Joseph Herman, Daniel Laheru, Stuart A. Grossman

Research output: Contribution to journalArticle

Abstract

Fifty-three patients with resected pancreatic adenocarcinoma were studied to determine if adjuvant chemo-radiation causes severe lymphopenia and if this is associated with adverse outcomes. Total lymphocyte counts (TLC) were normal in 91 before adjuvant chemo-radiation. Two months later, TLC fell by 63 (p < .0001) with 45 of patients having TLC < 500 cells/mm3. Median survival in patients with low TLC was 14 versus 20 months (p .048). Multivariate analysis revealed a significant association between treatment related lymphopenia and survival (HR 2.2, p .014). Adjuvant chemo-radiation induced lymphopenia is frequent, severe, and an independent predictor for survival in patients with resected pancreatic adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalCancer Investigation
Volume30
Issue number8
DOIs
StatePublished - Oct 2012

Keywords

  • Chemotherapy
  • Immunosuppression
  • Lymphopenia
  • Pancreatic cancer
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The association between treatment-related lymphopenia and survival in newly diagnosed patients with resected adenocarcinoma of the pancreas'. Together they form a unique fingerprint.

  • Cite this