The association between the ratio of monocytes: Lymphocytes and risk of tuberculosis among HIV-infected postpartum women

Vivek Naranbhai; Dhayendre Moodley; Tsungai Chipato; Lynda Stranix-Chibanda; Clemensia Nakabaiito; Moreen Kamateeka; Philippa Musoke; Karim Manji; Kathleen George; Lynda M. Emel; Paul Richardson; Philip Andrew; Mary Glenn Fowler; Helen Fletcher; Helen McShane; Hoosen M. Coovadia; Adrian V.S. Hill

doi:10.1097/qai.0000000000000353

The association between the ratio of monocytes: Lymphocytes and risk of tuberculosis among HIV-infected postpartum women

Vivek Naranbhai, Dhayendre Moodley, Tsungai Chipato, Lynda Stranix-Chibanda, Clemensia Nakabaiito, Moreen Kamateeka, Philippa Musoke, Karim Manji, Kathleen George, Lynda M. Emel, Paul Richardson, Philip Andrew, Mary Glenn Fowler, Helen Fletcher, Helen McShane, Hoosen M. Coovadia, Adrian V.S. Hill

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte: lymphocyte (ML) ratio and tuberculosis (TB) disease. To evaluate generalizability of this finding, we modeled the association between peripartum ML ratio and incident TB disease within 18 months postpartum among 1202 HIV-infected women in South Africa, Tanzania, Uganda, and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral therapy, World Health Organization stage, or CD4 count (adjusted hazard ratio = 1.22, 95% confidence interval: 1.07 to 1.4, P = 0.003 per 0.1 unit increase in ML ratio).

Original language	English (US)
Pages (from-to)	573-575
Number of pages	3
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	67
Issue number	5
DOIs	https://doi.org/10.1097/qai.0000000000000353
State	Published - 2014

Keywords

HIV
Lymphocytes
ML ratio
Monocytes
Pregnancy
Tuberculosis

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/qai.0000000000000353

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Naranbhai, V., Moodley, D., Chipato, T., Stranix-Chibanda, L., Nakabaiito, C., Kamateeka, M., Musoke, P., Manji, K., George, K., Emel, L. M., Richardson, P., Andrew, P., Fowler, M. G., Fletcher, H., McShane, H., Coovadia, H. M., & Hill, A. V. S. (2014). The association between the ratio of monocytes: Lymphocytes and risk of tuberculosis among HIV-infected postpartum women. Journal of Acquired Immune Deficiency Syndromes, 67(5), 573-575. https://doi.org/10.1097/qai.0000000000000353

Naranbhai, V, Moodley, D, Chipato, T, Stranix-Chibanda, L, Nakabaiito, C, Kamateeka, M, Musoke, P, Manji, K, George, K, Emel, LM, Richardson, P, Andrew, P, Fowler, MG, Fletcher, H, McShane, H, Coovadia, HM & Hill, AVS 2014, 'The association between the ratio of monocytes: Lymphocytes and risk of tuberculosis among HIV-infected postpartum women', Journal of Acquired Immune Deficiency Syndromes, vol. 67, no. 5, pp. 573-575. https://doi.org/10.1097/qai.0000000000000353

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abstract = "Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte: lymphocyte (ML) ratio and tuberculosis (TB) disease. To evaluate generalizability of this finding, we modeled the association between peripartum ML ratio and incident TB disease within 18 months postpartum among 1202 HIV-infected women in South Africa, Tanzania, Uganda, and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral therapy, World Health Organization stage, or CD4 count (adjusted hazard ratio = 1.22, 95% confidence interval: 1.07 to 1.4, P = 0.003 per 0.1 unit increase in ML ratio).",

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AU - Stranix-Chibanda, Lynda

AU - Nakabaiito, Clemensia

AU - Kamateeka, Moreen

AU - Musoke, Philippa

AU - Manji, Karim

AU - George, Kathleen

AU - Emel, Lynda M.

AU - Richardson, Paul

AU - Andrew, Philip

AU - Fowler, Mary Glenn

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AB - Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte: lymphocyte (ML) ratio and tuberculosis (TB) disease. To evaluate generalizability of this finding, we modeled the association between peripartum ML ratio and incident TB disease within 18 months postpartum among 1202 HIV-infected women in South Africa, Tanzania, Uganda, and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral therapy, World Health Organization stage, or CD4 count (adjusted hazard ratio = 1.22, 95% confidence interval: 1.07 to 1.4, P = 0.003 per 0.1 unit increase in ML ratio).

KW - HIV

KW - Lymphocytes

KW - ML ratio

KW - Monocytes

KW - Pregnancy

KW - Tuberculosis

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The association between the ratio of monocytes: Lymphocytes and risk of tuberculosis among HIV-infected postpartum women

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Keywords

ASJC Scopus subject areas

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