The association between the ratio of monocytes: Lymphocytes and risk of tuberculosis among HIV-infected postpartum women

Vivek Naranbhai, Dhayendre Moodley, Tsungai Chipato, Lynda Stranix-Chibanda, Clemensia Nakabaiito, Moreen Kamateeka, Philippa Musoke, Karim Manji, Kathleen George, Lynda M. Emel, Paul Richardson, Philip Andrew, Mary Glenn Fowler, Helen Fletcher, Helen McShane, Hoosen M. Coovadia, Adrian V.S. Hill

Research output: Contribution to journalArticlepeer-review

Abstract

Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte: lymphocyte (ML) ratio and tuberculosis (TB) disease. To evaluate generalizability of this finding, we modeled the association between peripartum ML ratio and incident TB disease within 18 months postpartum among 1202 HIV-infected women in South Africa, Tanzania, Uganda, and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral therapy, World Health Organization stage, or CD4 count (adjusted hazard ratio = 1.22, 95% confidence interval: 1.07 to 1.4, P = 0.003 per 0.1 unit increase in ML ratio).

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalJournal of acquired immune deficiency syndromes
Volume67
Issue number5
DOIs
StatePublished - 2014

Keywords

  • HIV
  • Lymphocytes
  • ML ratio
  • Monocytes
  • Pregnancy
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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