TY - JOUR
T1 - The Association between Preoperative Frailty and Postoperative Delirium after Cardiac Surgery
AU - Brown, Charles H.
AU - Max, Laura
AU - Laflam, Andrew
AU - Kirk, Lou
AU - Gross, Alden
AU - Arora, Rakesh
AU - Neufeld, Karin
AU - Hogue, Charles W.
AU - Walston, Jeremy
AU - Pustavoitau, Aliaksei
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) KL-2 Clinical Research Scholars Program, NIH (RO3 AG042331), the Jahnigen Career Development Award (Dr. Brown); Research Career Development Core of the Johns Hopkins University Claude D. Pepper Older Americans Independence Center, National Institute on Aging (NIA), P30AG021334 (Drs. Brown and Pustavoitau), NIH 1R01HL092259 (Dr. Hogue).
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Delirium is common after cardiac surgery, and preoperative identification of high-risk patients could guide prevention strategies. We prospectively measured frailty in 55 patients before cardiac surgery and assessed postoperative delirium using a validated chart review. The prevalence of frailty was 30.9%. Frail patients had a higher incidence of delirium (47.1%) compared with nonfrail patients (2.6%; P < 0.001). In multivariable models, the relative risk of delirium was ≥2.1-fold greater in frail compared with nonfrail patients (relative risk, 18.3; 95% confidence interval, 2.1-161.8; P = 0.009). Frailty may identify patients who would benefit from delirium-prevention strategies because of increased baseline risk for delirium.
AB - Delirium is common after cardiac surgery, and preoperative identification of high-risk patients could guide prevention strategies. We prospectively measured frailty in 55 patients before cardiac surgery and assessed postoperative delirium using a validated chart review. The prevalence of frailty was 30.9%. Frail patients had a higher incidence of delirium (47.1%) compared with nonfrail patients (2.6%; P < 0.001). In multivariable models, the relative risk of delirium was ≥2.1-fold greater in frail compared with nonfrail patients (relative risk, 18.3; 95% confidence interval, 2.1-161.8; P = 0.009). Frailty may identify patients who would benefit from delirium-prevention strategies because of increased baseline risk for delirium.
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U2 - 10.1213/ANE.0000000000001271
DO - 10.1213/ANE.0000000000001271
M3 - Article
C2 - 27096563
AN - SCOPUS:84964319017
VL - 123
SP - 430
EP - 435
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 2
ER -