The association between neighborhood socioeconomic disadvantage and chronic obstructive pulmonary disease

Panagis Galiatsatos, Han Woo, Laura M. Paulin, Amy Kind, Nirupama Putcha, Amanda J. Gassett, Christopher B. Cooper, Mark T. Dransfield, Trisha M. Parekh, Gabriela R. Oates, R. Graham Barr, Alejandro P. Comellas, Meilan K. Han, Stephen P. Peters, Jerry A. Krishnan, Wassim W. Labaki, Meredith C. McCormack, Joel D. Kaufman, Nadia N. Hansel

Research output: Contribution to journalArticlepeer-review

Abstract

Rationale: Individual socioeconomic status has been shown to influence the outcomes of patients with chronic obstructive pulmonary disease (COPD). However, contextual factors may also play a role. The objective of this study is to evaluate the association between neighborhood socioeconomic disadvantage measured by the area deprivation index (ADI) and COPD-related outcomes. Methods: Residential addresses of SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) subjects with COPD (FEV1 /FVC <0.70) at baseline were geocoded and linked to their respective ADI national ranking score at the census block group level. The associations between the ADI and COPD-related outcomes were evaluated by examining the contrast between participants living in the most-disadvantaged (top quin-tile) to the least-disadvantaged (bottom quintile) neighborhood. Regression models included adjustment for individual-level demographics, socioeconomic variables (personal income, education), exposures (smoking status, packs per year, occupational exposures), clinical characteristics (FEV1 % predicted, body mass index) and neighborhood rural status. Results: A total of 1800 participants were included in the analysis. Participants residing in the most-disadvantaged neighborhoods had 56% higher rate of COPD exacerbation (P<0.001), 98% higher rate of severe COPD exacerbation (P=0.001), a 1.6 point higher CAT score (P<0.001), 3.1 points higher SGRQ (P<0.001), and 24.6 meters less six-minute walk distance (P=0.008) compared with participants who resided in the least disadvantaged neighborhoods. Conclusion: Participants with COPD who reside in more-disadvantaged neighborhoods had worse COPD outcomes compared to those residing in less-disadvantaged neighborhoods. Neighborhood effects were independent of individual-level socioeconomic factors, suggest-ing that contextual factors could be used to inform intervention strategies targeting high-risk persons with COPD.

Original languageEnglish (US)
Pages (from-to)981-993
Number of pages13
JournalInternational Journal of COPD
Volume15
DOIs
StatePublished - 2020

Keywords

  • Area deprivation index
  • COPD
  • Health disparities

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

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