The association between midlife lipid levels and late-life brain amyloid deposition

Erin E. Bennett, Kan Z. Gianattasio, Timothy M. Hughes, Thomas H. Mosley, Dean F. Wong, Rebecca F. Gottesman, Melinda C. Power

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated low-density lipoprotein cholesterol and total cholesterol in midlife and decline in total cholesterol from mid- to late-life are associated with incident dementia. Whether brain amyloid deposition mediates this relationship is unclear. We explored the association between midlife blood lipid levels and mid- to late-life change in lipid levels with brain amyloid deposition assessed using florbetapir PET scans in a biracial sample of 325 nondemented participants of the Atherosclerosis Risk in Communities-PET Amyloid Imaging study. Midlife total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides were not significantly associated with late-life amyloid burden after adjusting for covariates. Associations between changes in lipids and late-life amyloid deposition were similarly null. Lipids may contribute to dementia risk through alternate mechanisms.

Original languageEnglish (US)
Pages (from-to)73-74
Number of pages2
JournalNeurobiology of aging
Volume92
DOIs
StatePublished - Aug 1 2020

Keywords

  • Alzheimer’s disease
  • Amyloid
  • Epidemiology
  • Lipids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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