The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

Kasper Broedbaek; Volkert Siersma; Jon T. Andersen; Morten Petersen; Shoaib Afzal; Brian Hjelvang; Allan Weimann; Richard D. Semba; Luigi Ferrucci; Henrik E. Poulsen

doi:10.3109/10715762.2010.538391

The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

Kasper Broedbaek, Volkert Siersma, Jon T. Andersen, Morten Petersen, Shoaib Afzal, Brian Hjelvang, Allan Weimann, Richard D. Semba, Luigi Ferrucci, Henrik E. Poulsen

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.

Original language	English (US)
Pages (from-to)	409-416
Number of pages	8
Journal	Free Radical Research
Volume	45
Issue number	4
DOIs	https://doi.org/10.3109/10715762.2010.538391
State	Published - Apr 2011

Keywords

8-hydroxy-2′-deoxyguanosine
8-oxo-7,8-dihydro-2′-deoxyguanosine
8-oxo-7,8-dihydroguanosine
8-oxoGuo
8-oxodG
DNA oxidation
infl ammation
iron

ASJC Scopus subject areas

Biochemistry

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10.3109/10715762.2010.538391

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title = "The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly",

abstract = "This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.",

keywords = "8-hydroxy-2′-deoxyguanosine, 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanosine, 8-oxoGuo, 8-oxodG, DNA oxidation, infl ammation, iron",

author = "Kasper Broedbaek and Volkert Siersma and Andersen, {Jon T.} and Morten Petersen and Shoaib Afzal and Brian Hjelvang and Allan Weimann and Semba, {Richard D.} and Luigi Ferrucci and Poulsen, {Henrik E.}",

note = "Funding Information: This study was supported by research funding from the Research Committee at Copenhagen University Hospital–Rigshospitalet. The authors report no conflicts of interest.The authors alone are responsible for the content and writing of the paper.",

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AU - Afzal, Shoaib

AU - Hjelvang, Brian

AU - Weimann, Allan

AU - Semba, Richard D.

AU - Ferrucci, Luigi

AU - Poulsen, Henrik E.

N1 - Funding Information: This study was supported by research funding from the Research Committee at Copenhagen University Hospital–Rigshospitalet. The authors report no conflicts of interest.The authors alone are responsible for the content and writing of the paper.

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N2 - This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.

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The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly

Abstract

Keywords

ASJC Scopus subject areas

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