Abstract
Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 758-777 |
| Number of pages | 20 |
| Journal | Journal of Aging and Health |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jun 1 2018 |
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Keywords
- biomarkers
- frailty
- Hispanics
- Latin America
ASJC Scopus subject areas
- Health(social science)
- Sociology and Political Science
- Gerontology
- Community and Home Care
- Geriatrics and Gerontology
- Life-span and Life-course Studies
Cite this
The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults. / Chanti-Ketterl, Marianne; Gamaldo, Alyssa; Andel, Ross; Thorpe, Roland J.
In: Journal of Aging and Health, Vol. 30, No. 5, 01.06.2018, p. 758-777.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults
AU - Chanti-Ketterl, Marianne
AU - Gamaldo, Alyssa
AU - Andel, Ross
AU - Thorpe, Roland J
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.
AB - Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.
KW - biomarkers
KW - frailty
KW - Hispanics
KW - Latin America
UR - http://www.scopus.com/inward/record.url?scp=85027462233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027462233&partnerID=8YFLogxK
U2 - 10.1177/0898264317690866
DO - 10.1177/0898264317690866
M3 - Article
VL - 30
SP - 758
EP - 777
JO - Journal of Aging and Health
JF - Journal of Aging and Health
SN - 0898-2643
IS - 5
ER -