The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults

Marianne Chanti-Ketterl, Alyssa Gamaldo, Ross Andel, Roland J Thorpe

Research output: Contribution to journalArticle

Abstract

Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.

Original languageEnglish (US)
Pages (from-to)758-777
Number of pages20
JournalJournal of Aging and Health
Volume30
Issue number5
DOIs
StatePublished - Jun 1 2018

Fingerprint

Lipoproteins
disability
Activities of Daily Living
HDL Cholesterol
Triglycerides
Cholesterol
performance
time
Lung
interaction

Keywords

  • biomarkers
  • frailty
  • Hispanics
  • Latin America

ASJC Scopus subject areas

  • Health(social science)
  • Sociology and Political Science
  • Gerontology
  • Community and Home Care
  • Geriatrics and Gerontology
  • Life-span and Life-course Studies

Cite this

The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults. / Chanti-Ketterl, Marianne; Gamaldo, Alyssa; Andel, Ross; Thorpe, Roland J.

In: Journal of Aging and Health, Vol. 30, No. 5, 01.06.2018, p. 758-777.

Research output: Contribution to journalArticle

Chanti-Ketterl, Marianne ; Gamaldo, Alyssa ; Andel, Ross ; Thorpe, Roland J. / The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults. In: Journal of Aging and Health. 2018 ; Vol. 30, No. 5. pp. 758-777.
@article{22108778fc70494c915d43370ed91c17,
title = "The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults",
abstract = "Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.",
keywords = "biomarkers, frailty, Hispanics, Latin America",
author = "Marianne Chanti-Ketterl and Alyssa Gamaldo and Ross Andel and Thorpe, {Roland J}",
year = "2018",
month = "6",
day = "1",
doi = "10.1177/0898264317690866",
language = "English (US)",
volume = "30",
pages = "758--777",
journal = "Journal of Aging and Health",
issn = "0898-2643",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults

AU - Chanti-Ketterl, Marianne

AU - Gamaldo, Alyssa

AU - Andel, Ross

AU - Thorpe, Roland J

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.

AB - Objective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance. Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study (n = 2,827). Lipoprotein profiles were measured using blood samples. Disability and physical functioning were measured with activities of daily living/instrumental activities of daily living (ADLs/IADLs) and objective assessment of physical performance. Results: Lower HDL-C was associated with greater ADL disability, and lower TC with longer time to pick-a-pencil and Time-Up-Go (TUG) test. Age interacted between (a) TG and lung function, chair stands, and pick-a-pencil, and (b) HDL-C and TUG. Stratification showed lower TG and longer time picking up a pencil only for those above 84 years. Based on significant interactions with sex, lower TC was associated with slower chair stand time in women and higher HDL-C with slower chair stand time in men. Discussion: Lower levels of lipoproteins may suggest worse physical function, but the association may differ by sex.

KW - biomarkers

KW - frailty

KW - Hispanics

KW - Latin America

UR - http://www.scopus.com/inward/record.url?scp=85027462233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027462233&partnerID=8YFLogxK

U2 - 10.1177/0898264317690866

DO - 10.1177/0898264317690866

M3 - Article

VL - 30

SP - 758

EP - 777

JO - Journal of Aging and Health

JF - Journal of Aging and Health

SN - 0898-2643

IS - 5

ER -