TY - JOUR
T1 - The association between intrauterine growth restriction in the full-term infant and high blood pressure at age 7 years
T2 - Results from the Collaborative Perinatal Project
AU - Hemachandra, Anusha H.
AU - Klebanoff, Mark A.
AU - Duggan, Anne K.
AU - Hardy, Janet B.
AU - Furth, Susan L.
N1 - Funding Information:
Drs A.H.H. and M.A.K. are supported by the intramural research program of the National Institute of Child Health and Human Development, National Institutes of Health. Dr A.K.D. is supported by the National Institute of Mental Health (1R03MH070333-01A1). Dr S.L.F. is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (U01DK66174).
PY - 2006/8
Y1 - 2006/8
N2 - Objective: To use neonatal and placental anthropometry as proxy measures of intrauterine growth restriction (IUGR) and to relate these to blood pressure later in childhood. Study design: A post hoc analysis of full-term white and black children from the Collaborative Perinatal Project, followed from birth until age 7 years (n = 29 710). Blood pressure above the 90th percentile by gender and race was considered high blood pressure. Anthropometric measures at birth included birth weight, ponderal index (PI, birth weight/birth length 3), head to chest circumference (HCC) ratio, and placental ratio percentage (PRP, placental weight*100/birth weight). Results: Among anthropometric measures, PI, HCC, and birth weight were not associated with high systolic blood pressure at age 7 years, but PRP was. In multiple logistic regression, high systolic blood pressure and widened pulse pressure were both predicted by increased PRP [odds ratio (OR) 1.03 and 1.04, P < 0.001] but not by birth weight, when adjusted for gender, race, and maternal education. High diastolic blood pressure was weakly predicted by birth weight (OR 1.10, P = 0.05) but not by PRP. Conclusions: PRP is associated with an increased risk for high systolic blood pressure and pulse pressure later in childhood, whereas birth weight, PI, and HCC are not. The proportion of placental weight to birth weight is a useful marker of IUGR for studying the developmental origins of adult disease hypothesis.
AB - Objective: To use neonatal and placental anthropometry as proxy measures of intrauterine growth restriction (IUGR) and to relate these to blood pressure later in childhood. Study design: A post hoc analysis of full-term white and black children from the Collaborative Perinatal Project, followed from birth until age 7 years (n = 29 710). Blood pressure above the 90th percentile by gender and race was considered high blood pressure. Anthropometric measures at birth included birth weight, ponderal index (PI, birth weight/birth length 3), head to chest circumference (HCC) ratio, and placental ratio percentage (PRP, placental weight*100/birth weight). Results: Among anthropometric measures, PI, HCC, and birth weight were not associated with high systolic blood pressure at age 7 years, but PRP was. In multiple logistic regression, high systolic blood pressure and widened pulse pressure were both predicted by increased PRP [odds ratio (OR) 1.03 and 1.04, P < 0.001] but not by birth weight, when adjusted for gender, race, and maternal education. High diastolic blood pressure was weakly predicted by birth weight (OR 1.10, P = 0.05) but not by PRP. Conclusions: PRP is associated with an increased risk for high systolic blood pressure and pulse pressure later in childhood, whereas birth weight, PI, and HCC are not. The proportion of placental weight to birth weight is a useful marker of IUGR for studying the developmental origins of adult disease hypothesis.
KW - Anthropometry
KW - Fetal programming
KW - Hypertension
KW - Neonatal
KW - Placenta
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U2 - 10.1093/ije/dyl080
DO - 10.1093/ije/dyl080
M3 - Article
C2 - 16766538
AN - SCOPUS:33749624226
SN - 0300-5771
VL - 35
SP - 871
EP - 877
JO - International journal of epidemiology
JF - International journal of epidemiology
IS - 4
ER -