Abstract
Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP). A total of 20 (10%) of psychiatric participants had a suicide attempt in the previous one month and 95 (45%) an attempt during their lifetime but not in the previous one month. The recent attempters had significantly elevated levels of antibodies to yeast mannan from Saccharomyces cerevisiae (ASCA), the food antigen gliadin, and bacterial lipopolysaccharide (LPS) compared with the non-psychiatric group when adjusting for demographic and clinical variables. These markers were not elevated in individuals with a past, but not recent, suicide attempt history. Our study indicates that there is evidence of gastrointestinal inflammation in some individuals who have had a recent suicide attempt.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8-12 |
| Number of pages | 5 |
| Journal | Psychiatry Research |
| Volume | 255 |
| DOIs | |
| State | Published - Sep 1 2017 |
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Keywords
- Attempted
- Biomarkers
- Gastrointestinal
- Inflammation
- Suicide
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
The association between immune markers and recent suicide attempts in patients with serious mental illness : A pilot study. / Dickerson, Faith; Adamos, Maria; Katsafanas, Emily; Khushalani, Sunil; Origoni, Andrea; Savage, Christina; Schweinfurth, Lucy; Stallings, Cassie; Sweeney, Kevin; Alaedini, Armin; Uhde, Melanie; Severance, Emily G; Wilcox, Holly; Yolken, Robert H.
In: Psychiatry Research, Vol. 255, 01.09.2017, p. 8-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association between immune markers and recent suicide attempts in patients with serious mental illness
T2 - A pilot study
AU - Dickerson, Faith
AU - Adamos, Maria
AU - Katsafanas, Emily
AU - Khushalani, Sunil
AU - Origoni, Andrea
AU - Savage, Christina
AU - Schweinfurth, Lucy
AU - Stallings, Cassie
AU - Sweeney, Kevin
AU - Alaedini, Armin
AU - Uhde, Melanie
AU - Severance, Emily G
AU - Wilcox, Holly
AU - Yolken, Robert H
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP). A total of 20 (10%) of psychiatric participants had a suicide attempt in the previous one month and 95 (45%) an attempt during their lifetime but not in the previous one month. The recent attempters had significantly elevated levels of antibodies to yeast mannan from Saccharomyces cerevisiae (ASCA), the food antigen gliadin, and bacterial lipopolysaccharide (LPS) compared with the non-psychiatric group when adjusting for demographic and clinical variables. These markers were not elevated in individuals with a past, but not recent, suicide attempt history. Our study indicates that there is evidence of gastrointestinal inflammation in some individuals who have had a recent suicide attempt.
AB - Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP). A total of 20 (10%) of psychiatric participants had a suicide attempt in the previous one month and 95 (45%) an attempt during their lifetime but not in the previous one month. The recent attempters had significantly elevated levels of antibodies to yeast mannan from Saccharomyces cerevisiae (ASCA), the food antigen gliadin, and bacterial lipopolysaccharide (LPS) compared with the non-psychiatric group when adjusting for demographic and clinical variables. These markers were not elevated in individuals with a past, but not recent, suicide attempt history. Our study indicates that there is evidence of gastrointestinal inflammation in some individuals who have had a recent suicide attempt.
KW - Attempted
KW - Biomarkers
KW - Gastrointestinal
KW - Inflammation
KW - Suicide
UR - http://www.scopus.com/inward/record.url?scp=85019070732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019070732&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2017.05.005
DO - 10.1016/j.psychres.2017.05.005
M3 - Article
C2 - 28505469
AN - SCOPUS:85019070732
VL - 255
SP - 8
EP - 12
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -