The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: the 2009–2010 National Health and Nutrition Examination Survey

Yuhan Huang, Dominique S. Michaud, Jiayun Lu, H. Ballentine Carter, Elizabeth A. Platz

Research output: Contribution to journalArticle

Abstract

Purpose: We evaluated the association between clinically assessed periodontal disease and serum prostate-specific antigen (PSA) concentration in men without a prostate cancer diagnosis in a US nationally representative sample of non-institutionalized men. Methods: Included were 1263 men aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey in 2009–2010. Measurements of periodontal health and tooth count were used to define periodontal disease severity (no, mild, moderate, severe) and edentulism. Linear and logistic regressions were used to estimate the association of periodontal disease severity and edentulism with PSA concentration and elevated PSA, respectively. Results: Adjusting for age and other factors including race, body mass index, and education, the natural logarithm of PSA concentration did not change with increasing severity (mild − 0.20, 95% confidence interval [CI] − 0.34 to − 0.05; moderate − 0.12, 95% CI − 0.26 to 0.01; severe − 0.16, 95% CI − 0.43 to 0.12; edentulism − 0.16, 95% CI − 0.35 to 0.04; P-trend 0.13) compared with dentate men without periodontal disease. Although the multivariable-adjusted ORs of elevated PSA were not statistically significant, participants with more severe periodontal disease were less likely to have PSA > 2.0 and > 2.5 ng/mL, but more likely to have PSA > 4.0 ng/mL, compared to dentate men without periodontal disease. Similar non-significant associations with PSA were observed when comparing edentulous men to dentate men without periodontal disease. Conclusions: In this US nationally representative sample, men with periodontal disease did not have higher serum PSA and were not more likely to have clinically elevated PSA after taking into account age and other factors, contrary to the hypothesis. This study suggests that periodontal disease does not notably affect the specificity of PSA for prostate cancer screening.

Original languageEnglish (US)
Pages (from-to)1293-1300
Number of pages8
JournalCancer Causes and Control
Volume30
Issue number12
DOIs
StatePublished - Dec 1 2019

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Nutrition Surveys
Periodontal Diseases
Prostate-Specific Antigen
Prostatic Neoplasms
Confidence Intervals
Age Factors
Serum
Early Detection of Cancer
Linear Models
Tooth
Body Mass Index
Logistic Models
Education

Keywords

  • Men
  • NHANES
  • Periodontal disease
  • PSA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

@article{8f94731c965f4b269828dde3b91766a5,
title = "The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: the 2009–2010 National Health and Nutrition Examination Survey",
abstract = "Purpose: We evaluated the association between clinically assessed periodontal disease and serum prostate-specific antigen (PSA) concentration in men without a prostate cancer diagnosis in a US nationally representative sample of non-institutionalized men. Methods: Included were 1263 men aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey in 2009–2010. Measurements of periodontal health and tooth count were used to define periodontal disease severity (no, mild, moderate, severe) and edentulism. Linear and logistic regressions were used to estimate the association of periodontal disease severity and edentulism with PSA concentration and elevated PSA, respectively. Results: Adjusting for age and other factors including race, body mass index, and education, the natural logarithm of PSA concentration did not change with increasing severity (mild − 0.20, 95{\%} confidence interval [CI] − 0.34 to − 0.05; moderate − 0.12, 95{\%} CI − 0.26 to 0.01; severe − 0.16, 95{\%} CI − 0.43 to 0.12; edentulism − 0.16, 95{\%} CI − 0.35 to 0.04; P-trend 0.13) compared with dentate men without periodontal disease. Although the multivariable-adjusted ORs of elevated PSA were not statistically significant, participants with more severe periodontal disease were less likely to have PSA > 2.0 and > 2.5 ng/mL, but more likely to have PSA > 4.0 ng/mL, compared to dentate men without periodontal disease. Similar non-significant associations with PSA were observed when comparing edentulous men to dentate men without periodontal disease. Conclusions: In this US nationally representative sample, men with periodontal disease did not have higher serum PSA and were not more likely to have clinically elevated PSA after taking into account age and other factors, contrary to the hypothesis. This study suggests that periodontal disease does not notably affect the specificity of PSA for prostate cancer screening.",
keywords = "Men, NHANES, Periodontal disease, PSA",
author = "Yuhan Huang and Michaud, {Dominique S.} and Jiayun Lu and Carter, {H. Ballentine} and Platz, {Elizabeth A.}",
year = "2019",
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volume = "30",
pages = "1293--1300",
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TY - JOUR

T1 - The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer

T2 - the 2009–2010 National Health and Nutrition Examination Survey

AU - Huang, Yuhan

AU - Michaud, Dominique S.

AU - Lu, Jiayun

AU - Carter, H. Ballentine

AU - Platz, Elizabeth A.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose: We evaluated the association between clinically assessed periodontal disease and serum prostate-specific antigen (PSA) concentration in men without a prostate cancer diagnosis in a US nationally representative sample of non-institutionalized men. Methods: Included were 1263 men aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey in 2009–2010. Measurements of periodontal health and tooth count were used to define periodontal disease severity (no, mild, moderate, severe) and edentulism. Linear and logistic regressions were used to estimate the association of periodontal disease severity and edentulism with PSA concentration and elevated PSA, respectively. Results: Adjusting for age and other factors including race, body mass index, and education, the natural logarithm of PSA concentration did not change with increasing severity (mild − 0.20, 95% confidence interval [CI] − 0.34 to − 0.05; moderate − 0.12, 95% CI − 0.26 to 0.01; severe − 0.16, 95% CI − 0.43 to 0.12; edentulism − 0.16, 95% CI − 0.35 to 0.04; P-trend 0.13) compared with dentate men without periodontal disease. Although the multivariable-adjusted ORs of elevated PSA were not statistically significant, participants with more severe periodontal disease were less likely to have PSA > 2.0 and > 2.5 ng/mL, but more likely to have PSA > 4.0 ng/mL, compared to dentate men without periodontal disease. Similar non-significant associations with PSA were observed when comparing edentulous men to dentate men without periodontal disease. Conclusions: In this US nationally representative sample, men with periodontal disease did not have higher serum PSA and were not more likely to have clinically elevated PSA after taking into account age and other factors, contrary to the hypothesis. This study suggests that periodontal disease does not notably affect the specificity of PSA for prostate cancer screening.

AB - Purpose: We evaluated the association between clinically assessed periodontal disease and serum prostate-specific antigen (PSA) concentration in men without a prostate cancer diagnosis in a US nationally representative sample of non-institutionalized men. Methods: Included were 1263 men aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey in 2009–2010. Measurements of periodontal health and tooth count were used to define periodontal disease severity (no, mild, moderate, severe) and edentulism. Linear and logistic regressions were used to estimate the association of periodontal disease severity and edentulism with PSA concentration and elevated PSA, respectively. Results: Adjusting for age and other factors including race, body mass index, and education, the natural logarithm of PSA concentration did not change with increasing severity (mild − 0.20, 95% confidence interval [CI] − 0.34 to − 0.05; moderate − 0.12, 95% CI − 0.26 to 0.01; severe − 0.16, 95% CI − 0.43 to 0.12; edentulism − 0.16, 95% CI − 0.35 to 0.04; P-trend 0.13) compared with dentate men without periodontal disease. Although the multivariable-adjusted ORs of elevated PSA were not statistically significant, participants with more severe periodontal disease were less likely to have PSA > 2.0 and > 2.5 ng/mL, but more likely to have PSA > 4.0 ng/mL, compared to dentate men without periodontal disease. Similar non-significant associations with PSA were observed when comparing edentulous men to dentate men without periodontal disease. Conclusions: In this US nationally representative sample, men with periodontal disease did not have higher serum PSA and were not more likely to have clinically elevated PSA after taking into account age and other factors, contrary to the hypothesis. This study suggests that periodontal disease does not notably affect the specificity of PSA for prostate cancer screening.

KW - Men

KW - NHANES

KW - Periodontal disease

KW - PSA

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