The association between circulating high-sensitivity C-reactive protein concentration and pathologic measures of colonic inflammation

Corinne E. Joshu, Kostantinos K. Tsilidis, Sarah B. Peskoe, Francis M Giardiello, Paul J. Dluzniewski, William G Nelson, Christine A. Iacobuzio-Donahue, Elizabeth A Platz

Research output: Contribution to journalArticle

Abstract

Purpose: C-reactive protein (CRP), an inflammation marker, is associated with colorectal cancer (CRC) risk in some prospective studies. Whether increased CRP is indicative of colonic inflammation, a possible CRC cause, or of other sources of inflammation (e.g., adiposity), is unknown. Thus, we evaluated the association between CRP and colonic mucosal measures of inflammation. Methods: 151 adults undergoing colonoscopy provided a blood sample and random left- and right-side colonic mucosal biopsies. Height and weight were measured, and lifestyle information was collected. High-sensitivity C-reactive protein (hsCRP) was measured by immunoturbidometric assay. A gastrointestinal pathologist evaluated biopsies for seven colonic inflammation measures. Of 119 participants with complete information, 24 had an inflammatory bowel disease (IBD) history and were analyzed separately. We calculated the number of colonic inflammation measures present in both biopsies, and separately for right and left biopsies. Adjusted geometric mean hsCRP was calculated using linear regression, overall, by demographic and lifestyle factors, and inflammation measures. Results: Most participants had ≥1 colonic inflammation measure (0: 21 %, 1: 39 %, ≥2: 40 %). Adjusted mean hsCRP did not increase with increasing number of inflammation measures (0: 1.67; 1: 1.33; ≥2: 1.01 mg/L; p trend = 0.21). Obese (2.03 mg/L) and overweight (1.61 mg/L) participants had higher adjusted mean hsCRP than normal-weight participants (0.62 mg/L; p trend

Original languageEnglish (US)
Pages (from-to)409-418
Number of pages10
JournalCancer Causes and Control
Volume25
Issue number4
DOIs
StatePublished - 2014

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C-Reactive Protein
Inflammation
Biopsy
Life Style
Colorectal Neoplasms
Weights and Measures
Adiposity
Colonoscopy
Linear Models
Demography
Prospective Studies

Keywords

  • C-reactive protein
  • Colorectal cancer
  • Inflammation
  • Obesity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The association between circulating high-sensitivity C-reactive protein concentration and pathologic measures of colonic inflammation. / Joshu, Corinne E.; Tsilidis, Kostantinos K.; Peskoe, Sarah B.; Giardiello, Francis M; Dluzniewski, Paul J.; Nelson, William G; Iacobuzio-Donahue, Christine A.; Platz, Elizabeth A.

In: Cancer Causes and Control, Vol. 25, No. 4, 2014, p. 409-418.

Research output: Contribution to journalArticle

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abstract = "Purpose: C-reactive protein (CRP), an inflammation marker, is associated with colorectal cancer (CRC) risk in some prospective studies. Whether increased CRP is indicative of colonic inflammation, a possible CRC cause, or of other sources of inflammation (e.g., adiposity), is unknown. Thus, we evaluated the association between CRP and colonic mucosal measures of inflammation. Methods: 151 adults undergoing colonoscopy provided a blood sample and random left- and right-side colonic mucosal biopsies. Height and weight were measured, and lifestyle information was collected. High-sensitivity C-reactive protein (hsCRP) was measured by immunoturbidometric assay. A gastrointestinal pathologist evaluated biopsies for seven colonic inflammation measures. Of 119 participants with complete information, 24 had an inflammatory bowel disease (IBD) history and were analyzed separately. We calculated the number of colonic inflammation measures present in both biopsies, and separately for right and left biopsies. Adjusted geometric mean hsCRP was calculated using linear regression, overall, by demographic and lifestyle factors, and inflammation measures. Results: Most participants had ≥1 colonic inflammation measure (0: 21 {\%}, 1: 39 {\%}, ≥2: 40 {\%}). Adjusted mean hsCRP did not increase with increasing number of inflammation measures (0: 1.67; 1: 1.33; ≥2: 1.01 mg/L; p trend = 0.21). Obese (2.03 mg/L) and overweight (1.61 mg/L) participants had higher adjusted mean hsCRP than normal-weight participants (0.62 mg/L; p trend",
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AU - Giardiello, Francis M

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