The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls

Faith Dickerson, Maria B. Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina L.G. Savage, Jennifer Schroeder, Lucy A.B. Schweinfurth, Cassie Stallings, Kevin Sweeney, Robert Yolken

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Previous investigations have found that smokers with schizophrenia demonstrate reduced performance on cognitive tasks compared to non-smokers. However previous studies have not taken into account other environmental factors associated with cognitive functioning such as exposure to Herpes Simplex Virus type 1 (HSV-1). We examined these factors in a sample consisting of individuals with schizophrenia (n = 773), bipolar disorder (n = 493), or controls without a psychiatric disorders (n = 548). Participants were assessed on a cognitive battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and had a blood sample drawn to measure seropositivity to HSV-1. Within each group linear regression models were constructed to determine whether cigarette smoking and HSV-1 seropositivity were jointly associated with cognitive functioning after adjusting for relevant covariates. Within the schizophrenia group, the effect size of lower total cognitive score was − 0.279 (p < 0.0001) for individuals who were both smokers and HSV-1 seropositive and a significant effect was found in all cognitive domains. The odds of being in the highest quartile of RBANS Total score were significantly lower for smokers (OR = 0.58, 95% CI 0.41, 0.82, p = 0.002). Smoking was not as consistently associated with levels of cognitive functioning in the bipolar disorder or the non-psychiatric control group. While experimental studies show that nicotine transiently improves functioning on sensory gating and attention tasks known to be deficient in schizophrenia, long-term nicotine exposure via smoking appears to have an adverse effect on cognitive functioning.

Original languageEnglish (US)
Pages (from-to)566-571
Number of pages6
JournalSchizophrenia Research
Volume176
Issue number2-3
DOIs
StatePublished - Oct 1 2016

Keywords

  • Bipolar disorder
  • Cognitive
  • Herpes virus
  • Nicotine
  • Schizophrenia
  • Smoking

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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