The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls

Faith Dickerson, Maria B. Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina L G Savage, Jennifer Schroeder, Lucy A B Schweinfurth, Cassie Stallings, Kevin Sweeney, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Previous investigations have found that smokers with schizophrenia demonstrate reduced performance on cognitive tasks compared to non-smokers. However previous studies have not taken into account other environmental factors associated with cognitive functioning such as exposure to Herpes Simplex Virus type 1 (HSV-1). We examined these factors in a sample consisting of individuals with schizophrenia (n = 773), bipolar disorder (n = 493), or controls without a psychiatric disorders (n = 548). Participants were assessed on a cognitive battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and had a blood sample drawn to measure seropositivity to HSV-1. Within each group linear regression models were constructed to determine whether cigarette smoking and HSV-1 seropositivity were jointly associated with cognitive functioning after adjusting for relevant covariates. Within the schizophrenia group, the effect size of lower total cognitive score was -0.279 (p

Original languageEnglish (US)
JournalSchizophrenia Research
DOIs
StateAccepted/In press - Feb 18 2016

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Human Herpesvirus 1
Bipolar Disorder
Schizophrenia
Smoking
Linear Models
Psychiatry

Keywords

  • Bipolar disorder
  • Cognitive
  • Herpes virus
  • Nicotine
  • Schizophrenia
  • Smoking

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls. / Dickerson, Faith; Adamos, Maria B.; Katsafanas, Emily; Khushalani, Sunil; Origoni, Andrea; Savage, Christina L G; Schroeder, Jennifer; Schweinfurth, Lucy A B; Stallings, Cassie; Sweeney, Kevin; Yolken, Robert H.

In: Schizophrenia Research, 18.02.2016.

Research output: Contribution to journalArticle

Dickerson, F, Adamos, MB, Katsafanas, E, Khushalani, S, Origoni, A, Savage, CLG, Schroeder, J, Schweinfurth, LAB, Stallings, C, Sweeney, K & Yolken, RH 2016, 'The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls', Schizophrenia Research. https://doi.org/10.1016/j.schres.2016.05.022
Dickerson, Faith ; Adamos, Maria B. ; Katsafanas, Emily ; Khushalani, Sunil ; Origoni, Andrea ; Savage, Christina L G ; Schroeder, Jennifer ; Schweinfurth, Lucy A B ; Stallings, Cassie ; Sweeney, Kevin ; Yolken, Robert H. / The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls. In: Schizophrenia Research. 2016.
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