The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls

Faith Dickerson, Maria B. Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina L G Savage, Jennifer Schroeder, Lucy A B Schweinfurth, Cassie Stallings, Kevin Sweeney, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Previous investigations have found that smokers with schizophrenia demonstrate reduced performance on cognitive tasks compared to non-smokers. However previous studies have not taken into account other environmental factors associated with cognitive functioning such as exposure to Herpes Simplex Virus type 1 (HSV-1). We examined these factors in a sample consisting of individuals with schizophrenia (n = 773), bipolar disorder (n = 493), or controls without a psychiatric disorders (n = 548). Participants were assessed on a cognitive battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and had a blood sample drawn to measure seropositivity to HSV-1. Within each group linear regression models were constructed to determine whether cigarette smoking and HSV-1 seropositivity were jointly associated with cognitive functioning after adjusting for relevant covariates. Within the schizophrenia group, the effect size of lower total cognitive score was -0.279 (p

Original languageEnglish (US)
JournalSchizophrenia Research
DOIs
StateAccepted/In press - Feb 18 2016

Keywords

  • Bipolar disorder
  • Cognitive
  • Herpes virus
  • Nicotine
  • Schizophrenia
  • Smoking

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Dickerson, F., Adamos, M. B., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C. L. G., Schroeder, J., Schweinfurth, L. A. B., Stallings, C., Sweeney, K., & Yolken, R. H. (Accepted/In press). The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls. Schizophrenia Research. https://doi.org/10.1016/j.schres.2016.05.022