TY - JOUR
T1 - The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study
T2 - Design and methods
AU - Go, Alan S.
AU - Parikh, Chirag R.
AU - Ikizler, T. Alp
AU - Coca, Steven
AU - Siew, Edward D.
AU - Chinchilli, Vernon M.
AU - Hsu, Chi Yuan
AU - Garg, Amit X.
AU - Zappitelli, Michael
AU - Liu, Kathleen D.
AU - Reeves, W. Brian
AU - Ghahramani, Nasrollah
AU - Devarajan, Prasad
AU - Faulkner, Georgia Brown
AU - Tan, Thida C.
AU - Kimmel, Paul L.
AU - Eggers, Paul
AU - Stokes, John B.
N1 - Funding Information:
Supported by research grants U01-DK082223, U01-DK082185, U01DK082192 and U01DK082183 from the National Institute of Digestive, Diabetes and Kidney Diseases of the National Institutes of Health, U.S. Department of Health and Human Services. The following are members of the ASSESS-AKI Consortium: Clinical Research Centers Kaiser Permanente Northern California Alan S. Go, MD (Principal Investigator) Chi-yuan Hsu, MD, MSc (University of California, San Francisco) Kathleen D. Liu, MD, PhD (University of California, San Francisco) Juan D. Ordoñez, MD, MPH Tracy Jonelis, MD Mubasha Rana, MD Thida C. Tan, MPH Daniel Fernandez Vanderbilt University T. Alp Ikizler, MD, FASN (Principal Investigator) Edward D. Siew, MD, MSCI Lorraine B. Ware, MD Julia B. Lewis, MD TRIBE-AKI Consortium Chirag R. Parikh, MD, MPH (Principal Investigator, Yale University) Steven Coca, DO, MS (Yale University) Amit X. Garg, MD, MA, PhD (London Health Sciences Centre) Prasad Devarajan, MD (Cincinnati Children’s Hospital Medical Center) Zhu Wang, PhD (Yale University) Michael Zappitelli, MD, MSc (Montreal Children’s Hospital) Elizabeth Dombrowski, MS, MBA (Yale University) Catherine Krawczeski, MD (Cincinnati Children’s Hospital Medical Center) Virginia Schuman (London Health Sciences Center) Rowena Kemp (Yale University) Data Coordinating Center Pennsylvania State University Vernon M. Chinchilli, PhD (Principal Investigator) W. Brian Reeves, MD Nasrollah Ghahramani, MD, MS Chuntao Wu, MD, PhD Georgia Brown Faulkner, RN, BSN Steering Committee Chair University of Iowa John B. Stokes, MD The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Paul L. Kimmel, MD (Project Officer) Paul Eggers, PhD (Project Officer)
PY - 2010
Y1 - 2010
N2 - Background: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. Methods: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardiovascular events, death, and other important patient-centered outcomes. This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers. Participants will be followed for up to four years, and will undergo serial evaluation during the index hospitalization, at three months post-hospitalization, and at annual clinic visits, with telephone interviews occurring during the intervening six-month intervals. Biospecimens will be collected at each visit, along with information on lifestyle behaviors, quality of life and functional status, cognitive function, receipt of therapies, interim renal and cardiovascular events, electrocardiography and urinalysis. Conclusions: ASSESS-AKI will characterize the short-term and long-term natural history of AKI, evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI, and identify a subset of high-risk patients who could be targeted for future clinical trials to improve outcomes after AKI.
AB - Background: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. Methods: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardiovascular events, death, and other important patient-centered outcomes. This prospective study will enroll a cohort of 1100 adult participants with a broad range of AKI and matched hospitalized participants without AKI at three Clinical Research Centers, as well as 100 children undergoing cardiac surgery at three Clinical Research Centers. Participants will be followed for up to four years, and will undergo serial evaluation during the index hospitalization, at three months post-hospitalization, and at annual clinic visits, with telephone interviews occurring during the intervening six-month intervals. Biospecimens will be collected at each visit, along with information on lifestyle behaviors, quality of life and functional status, cognitive function, receipt of therapies, interim renal and cardiovascular events, electrocardiography and urinalysis. Conclusions: ASSESS-AKI will characterize the short-term and long-term natural history of AKI, evaluate the incremental utility of novel blood and urine biomarkers to refine the diagnosis and prognosis of AKI, and identify a subset of high-risk patients who could be targeted for future clinical trials to improve outcomes after AKI.
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U2 - 10.1186/1471-2369-11-22
DO - 10.1186/1471-2369-11-22
M3 - Article
C2 - 20799966
AN - SCOPUS:77955972575
SN - 1471-2369
VL - 11
JO - BMC nephrology
JF - BMC nephrology
IS - 1
M1 - 22
ER -