The art of choreographing asymmetric cell division

Rong Li

doi:10.1016/j.devcel.2013.05.003

The art of choreographing asymmetric cell division

Rong Li

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Asymmetric cell division (ACD), a mechanism for cell-type diversification in both prokaryotes and eukaryotes, is accomplished through highly coordinated cell-fate segregation, genome partitioning, and cell division. Whereas important paradigms have arisen from the study of animal embryonic divisions, the strategies for choreographing the dynamic subprocesses are, in fact, highly varied. This review examines divergent mechanisms of ACD across different kingdoms. Examples discussed show that there is no obligatory hierarchy among the dynamic events and that asymmetry can emerge from each event, but cell polarization more often occurs as the initial instructive process for patterning ACD especially in the multicellular context.

Original language	English (US)
Pages (from-to)	439-450
Number of pages	12
Journal	Developmental Cell
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2013.05.003
State	Published - Jun 10 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2013.05.003

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title = "The art of choreographing asymmetric cell division",

abstract = "Asymmetric cell division (ACD), a mechanism for cell-type diversification in both prokaryotes and eukaryotes, is accomplished through highly coordinated cell-fate segregation, genome partitioning, and cell division. Whereas important paradigms have arisen from the study of animal embryonic divisions, the strategies for choreographing the dynamic subprocesses are, in fact, highly varied. This review examines divergent mechanisms of ACD across different kingdoms. Examples discussed show that there is no obligatory hierarchy among the dynamic events and that asymmetry can emerge from each event, but cell polarization more often occurs as the initial instructive process for patterning ACD especially in the multicellular context.",

author = "Rong Li",

note = "Funding Information: Due to space constraints, the author apologizes to many researchers whose work is not cited or not cited fully. The work on asymmetric cell division in the author{\textquoteright}s lab is supported by a grant from the National Institutes of Health (GM-RO1-057063).",

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N1 - Funding Information: Due to space constraints, the author apologizes to many researchers whose work is not cited or not cited fully. The work on asymmetric cell division in the author’s lab is supported by a grant from the National Institutes of Health (GM-RO1-057063).

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N2 - Asymmetric cell division (ACD), a mechanism for cell-type diversification in both prokaryotes and eukaryotes, is accomplished through highly coordinated cell-fate segregation, genome partitioning, and cell division. Whereas important paradigms have arisen from the study of animal embryonic divisions, the strategies for choreographing the dynamic subprocesses are, in fact, highly varied. This review examines divergent mechanisms of ACD across different kingdoms. Examples discussed show that there is no obligatory hierarchy among the dynamic events and that asymmetry can emerge from each event, but cell polarization more often occurs as the initial instructive process for patterning ACD especially in the multicellular context.

AB - Asymmetric cell division (ACD), a mechanism for cell-type diversification in both prokaryotes and eukaryotes, is accomplished through highly coordinated cell-fate segregation, genome partitioning, and cell division. Whereas important paradigms have arisen from the study of animal embryonic divisions, the strategies for choreographing the dynamic subprocesses are, in fact, highly varied. This review examines divergent mechanisms of ACD across different kingdoms. Examples discussed show that there is no obligatory hierarchy among the dynamic events and that asymmetry can emerge from each event, but cell polarization more often occurs as the initial instructive process for patterning ACD especially in the multicellular context.

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The art of choreographing asymmetric cell division

Abstract

ASJC Scopus subject areas

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