The ARP2/3 complex: An actin nucleator comes of age

Erin D. Goley, Matthew D. Welch

Research output: Contribution to journalReview articlepeer-review

615 Scopus citations


The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.

Original languageEnglish (US)
Pages (from-to)713-726
Number of pages14
JournalNature Reviews Molecular Cell Biology
Issue number10
StatePublished - Oct 23 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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