Abstract
The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.
Original language | English (US) |
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Pages (from-to) | 713-726 |
Number of pages | 14 |
Journal | Nature Reviews Molecular Cell Biology |
Volume | 7 |
Issue number | 10 |
DOIs | |
State | Published - Oct 23 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology