The ARP2/3 complex: An actin nucleator comes of age

Erin D. Goley, Matthew D. Welch

Research output: Contribution to journalReview articlepeer-review

615 Scopus citations

Abstract

The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.

Original languageEnglish (US)
Pages (from-to)713-726
Number of pages14
JournalNature Reviews Molecular Cell Biology
Volume7
Issue number10
DOIs
StatePublished - Oct 23 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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