The ARIC-PET amyloid imaging study

Brain amyloid differences by age, race, sex, and APOE

Rebecca F Gottesman, Andrea L C Schneider, Yun Zhou, Xueqi Chen, Edward Green, Naresh Gupta, David S. Knopman, Akiva Mintz, Arman Rahmim, A. Richey Sharrett, Lynne E. Wagenknecht, Dean Foster Wong, Thomas H. Mosley

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE ϵ4 allele status. Methods: Recruited from the longitudinal Atherosclerosis Risk in Communities study, 329 participants without dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). Standardized uptake value ratios (SUVRs) were calculated; global cortical SUVR >1.2 was evaluated as the primary outcome. Age, race, sex, education level, and number of APOE ϵ4 alleles were evaluated in multivariable models including vascular risk factors, brain white matter hyperintensity and total intracranial volume, and cognitive status. Results: A total of 141 of the participants (43%) were black. In multivariable models, odds of elevated SUVR was increased in participants with increasing age (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.01-2.65 per 10 years of age) and black race (OR 2.08, 95% CI 1.23-3.51) but did not differ by educational level. Each ϵ4 allele was associated with increased odds of elevated SUVR (OR 2.65, 95% CI 1.61-4.39). Conclusions: In this community-based cohort without dementia, florbetapir uptake is associated with older age and APOE genotype. Black race was associated with higher SUVR, after adjusting for demographics, vascular risk factors, cognitive status, white matter hyperintensity volume, and APOE genotype, with effect sizes nearing those seen for APOE ϵ4. Replication of these findings is needed in other cohorts, and reasons for and consequences of these observed differences by race warrant further study.

Original languageEnglish (US)
Pages (from-to)473-480
Number of pages8
JournalNeurology
Volume87
Issue number5
DOIs
StatePublished - Aug 2 2016

Fingerprint

Amyloid
Neuroimaging
Dementia
Sex Education
Alleles
Odds Ratio
Confidence Intervals
Genotype
Mississippi
Atherosclerosis
Demography
Brain
vascular factor
florbetapir
White Matter

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Gottesman, R. F., Schneider, A. L. C., Zhou, Y., Chen, X., Green, E., Gupta, N., ... Mosley, T. H. (2016). The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE. Neurology, 87(5), 473-480. https://doi.org/10.1212/WNL.0000000000002914

The ARIC-PET amyloid imaging study : Brain amyloid differences by age, race, sex, and APOE. / Gottesman, Rebecca F; Schneider, Andrea L C; Zhou, Yun; Chen, Xueqi; Green, Edward; Gupta, Naresh; Knopman, David S.; Mintz, Akiva; Rahmim, Arman; Sharrett, A. Richey; Wagenknecht, Lynne E.; Wong, Dean Foster; Mosley, Thomas H.

In: Neurology, Vol. 87, No. 5, 02.08.2016, p. 473-480.

Research output: Contribution to journalArticle

Gottesman, RF, Schneider, ALC, Zhou, Y, Chen, X, Green, E, Gupta, N, Knopman, DS, Mintz, A, Rahmim, A, Sharrett, AR, Wagenknecht, LE, Wong, DF & Mosley, TH 2016, 'The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE', Neurology, vol. 87, no. 5, pp. 473-480. https://doi.org/10.1212/WNL.0000000000002914
Gottesman, Rebecca F ; Schneider, Andrea L C ; Zhou, Yun ; Chen, Xueqi ; Green, Edward ; Gupta, Naresh ; Knopman, David S. ; Mintz, Akiva ; Rahmim, Arman ; Sharrett, A. Richey ; Wagenknecht, Lynne E. ; Wong, Dean Foster ; Mosley, Thomas H. / The ARIC-PET amyloid imaging study : Brain amyloid differences by age, race, sex, and APOE. In: Neurology. 2016 ; Vol. 87, No. 5. pp. 473-480.
@article{14d5738c676843e682016f9a1a9a3dbd,
title = "The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE",
abstract = "Objective: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE ϵ4 allele status. Methods: Recruited from the longitudinal Atherosclerosis Risk in Communities study, 329 participants without dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). Standardized uptake value ratios (SUVRs) were calculated; global cortical SUVR >1.2 was evaluated as the primary outcome. Age, race, sex, education level, and number of APOE ϵ4 alleles were evaluated in multivariable models including vascular risk factors, brain white matter hyperintensity and total intracranial volume, and cognitive status. Results: A total of 141 of the participants (43{\%}) were black. In multivariable models, odds of elevated SUVR was increased in participants with increasing age (odds ratio [OR] 1.63, 95{\%} confidence interval [CI] 1.01-2.65 per 10 years of age) and black race (OR 2.08, 95{\%} CI 1.23-3.51) but did not differ by educational level. Each ϵ4 allele was associated with increased odds of elevated SUVR (OR 2.65, 95{\%} CI 1.61-4.39). Conclusions: In this community-based cohort without dementia, florbetapir uptake is associated with older age and APOE genotype. Black race was associated with higher SUVR, after adjusting for demographics, vascular risk factors, cognitive status, white matter hyperintensity volume, and APOE genotype, with effect sizes nearing those seen for APOE ϵ4. Replication of these findings is needed in other cohorts, and reasons for and consequences of these observed differences by race warrant further study.",
author = "Gottesman, {Rebecca F} and Schneider, {Andrea L C} and Yun Zhou and Xueqi Chen and Edward Green and Naresh Gupta and Knopman, {David S.} and Akiva Mintz and Arman Rahmim and Sharrett, {A. Richey} and Wagenknecht, {Lynne E.} and Wong, {Dean Foster} and Mosley, {Thomas H.}",
year = "2016",
month = "8",
day = "2",
doi = "10.1212/WNL.0000000000002914",
language = "English (US)",
volume = "87",
pages = "473--480",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - The ARIC-PET amyloid imaging study

T2 - Brain amyloid differences by age, race, sex, and APOE

AU - Gottesman, Rebecca F

AU - Schneider, Andrea L C

AU - Zhou, Yun

AU - Chen, Xueqi

AU - Green, Edward

AU - Gupta, Naresh

AU - Knopman, David S.

AU - Mintz, Akiva

AU - Rahmim, Arman

AU - Sharrett, A. Richey

AU - Wagenknecht, Lynne E.

AU - Wong, Dean Foster

AU - Mosley, Thomas H.

PY - 2016/8/2

Y1 - 2016/8/2

N2 - Objective: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE ϵ4 allele status. Methods: Recruited from the longitudinal Atherosclerosis Risk in Communities study, 329 participants without dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). Standardized uptake value ratios (SUVRs) were calculated; global cortical SUVR >1.2 was evaluated as the primary outcome. Age, race, sex, education level, and number of APOE ϵ4 alleles were evaluated in multivariable models including vascular risk factors, brain white matter hyperintensity and total intracranial volume, and cognitive status. Results: A total of 141 of the participants (43%) were black. In multivariable models, odds of elevated SUVR was increased in participants with increasing age (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.01-2.65 per 10 years of age) and black race (OR 2.08, 95% CI 1.23-3.51) but did not differ by educational level. Each ϵ4 allele was associated with increased odds of elevated SUVR (OR 2.65, 95% CI 1.61-4.39). Conclusions: In this community-based cohort without dementia, florbetapir uptake is associated with older age and APOE genotype. Black race was associated with higher SUVR, after adjusting for demographics, vascular risk factors, cognitive status, white matter hyperintensity volume, and APOE genotype, with effect sizes nearing those seen for APOE ϵ4. Replication of these findings is needed in other cohorts, and reasons for and consequences of these observed differences by race warrant further study.

AB - Objective: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE ϵ4 allele status. Methods: Recruited from the longitudinal Atherosclerosis Risk in Communities study, 329 participants without dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). Standardized uptake value ratios (SUVRs) were calculated; global cortical SUVR >1.2 was evaluated as the primary outcome. Age, race, sex, education level, and number of APOE ϵ4 alleles were evaluated in multivariable models including vascular risk factors, brain white matter hyperintensity and total intracranial volume, and cognitive status. Results: A total of 141 of the participants (43%) were black. In multivariable models, odds of elevated SUVR was increased in participants with increasing age (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.01-2.65 per 10 years of age) and black race (OR 2.08, 95% CI 1.23-3.51) but did not differ by educational level. Each ϵ4 allele was associated with increased odds of elevated SUVR (OR 2.65, 95% CI 1.61-4.39). Conclusions: In this community-based cohort without dementia, florbetapir uptake is associated with older age and APOE genotype. Black race was associated with higher SUVR, after adjusting for demographics, vascular risk factors, cognitive status, white matter hyperintensity volume, and APOE genotype, with effect sizes nearing those seen for APOE ϵ4. Replication of these findings is needed in other cohorts, and reasons for and consequences of these observed differences by race warrant further study.

UR - http://www.scopus.com/inward/record.url?scp=84982994428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982994428&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000002914

DO - 10.1212/WNL.0000000000002914

M3 - Article

VL - 87

SP - 473

EP - 480

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5

ER -