The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss

Lyndon Da Cruz, Brian F. Coley, Jessy Dorn, Francesco Merlini, Eugene Filley, Punita Christopher, Fred K. Chen, Varalakshmi Wuyyuru, Jose Sahel, Paulo Stanga, Mark Humayun, Robert J. Greenberg, Gislin Dagnelie

Research output: Contribution to journalArticlepeer-review

Abstract

Background Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, longterm retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. Methods We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three-and fourletter word identification tests were carried out. Results The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.37plusmn;24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0 ±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three-and four-letter words. Average implant duration was 19.9 months. Conclusions Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.

Original languageEnglish (US)
Pages (from-to)632-636
Number of pages5
JournalBritish Journal of Ophthalmology
Volume97
Issue number5
DOIs
StatePublished - May 2013

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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