TY - JOUR
T1 - The aquaporin family of membrane water channels
AU - Engel, Andreas
AU - Walz, Thomas
AU - Agre, Peter
N1 - Funding Information:
We are grateful to U Aebi for his continuous support and critical discussions, to G Preston for his help with the manuscript, and to D Brown for providing the micrograph shown in Fig lb. The work was supported by the ME Miiller Foundation of Switzerland, by the Swiss National Foundation for Scientific Research grant 31-32536.91 (to AE), and by National Institutes of Health grants HL33991and HL48268 (to PA).
PY - 1994
Y1 - 1994
N2 - The rapid movement of water across the plasma membranes of certain cells has been a long-standing puzzle to membrane biophysicists and physiologists; the discovery of the red cell channel-forming integral protein has provided a molecular solution to this puzzle. The identification of this protein has led to the recognition of a family of related water-selective channels, the aquaporins, that are found in animals, plants and microbial organisms. In order to provide insight into the remarkable but simple function of these membrane proteins, their structures are being elucidated.
AB - The rapid movement of water across the plasma membranes of certain cells has been a long-standing puzzle to membrane biophysicists and physiologists; the discovery of the red cell channel-forming integral protein has provided a molecular solution to this puzzle. The identification of this protein has led to the recognition of a family of related water-selective channels, the aquaporins, that are found in animals, plants and microbial organisms. In order to provide insight into the remarkable but simple function of these membrane proteins, their structures are being elucidated.
UR - http://www.scopus.com/inward/record.url?scp=0028170113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028170113&partnerID=8YFLogxK
U2 - 10.1016/S0959-440X(94)90217-8
DO - 10.1016/S0959-440X(94)90217-8
M3 - Article
AN - SCOPUS:0028170113
SN - 0959-440X
VL - 4
SP - 545
EP - 553
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 4
ER -