The application of thermodynamic methods in drug design

Physics & Astronomy

• drugs 69%
• ligands 54%
• thermodynamics 46%
• affinity 42%
• enthalpy 20%
• mutations 17%
• optimization 15%
• lead compounds 12%
• protease 11%
• human immunodeficiency virus 11%
• entropy 11%
• polymorphism 9%
• inhibitors 8%
• penalties 8%
• flexibility 6%
• signatures 6%
• magnetic permeability 5%
• geometry 4%
• energy 2%

Chemical Compounds

• Thermodynamic Method 100%
• Kd 37%
• Drug 36%
• Ligand 30%
• Enthalpy 23%
• Application 21%
• Mutation 16%
• Entropy 16%
• Genetic Polymorphism 15%
• G Value 13%
• Thermodynamics 12%
• Protease Inhibitor 11%
• Flexibility 7%
• Gibbs Free Energy 7%
• Binding Site 6%

Engineering & Materials Science

• Ligands 91%
• Thermodynamics 59%
• Enthalpy 30%
• Lead compounds 16%
• Entropy 16%
• Peptide Hydrolases 14%
• Binding sites 13%
• Gibbs free energy 13%
• Polymorphism 12%
• Relaxation 9%
• Geometry 5%