The application of positron emission tomographic imaging with fluorodeoxyglucose to the evaluation of breast disease

Nielson Y. Tse, Carl K. Hoh, Randall A. Hawkins, Michael J. Zinner, Magnus Dahlbom, Yong Choi, Jamshid Maddahi, F. Charles Brunicardi, Michael E. Phelps, John A. Glaspy

Research output: Contribution to journalArticle

Abstract

Positron emission tomography (PET) is a computer-aided tomographic imaging technique that uses positron-emitting compounds to trace biochemical processes of tissue, and construct images based on them. The authors applied a whole-body PET imaging technique to patients with breast masses or mammographic abnormalities using the isotope 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG), in a clinical trial to evaluate the feasibility of using PET to identify primary breast cancer, axillary lymph node involvement, and systemic metastases, before surgical resection. Fourteen patients have been entered on this study, 10 of whom proved to have breast cancer. Positron emission tomography correctly predicted the nature of 12 of the 14 primary breast lesions, and correctly determined the lymph node status of 11 of the 14 patients. The authors conclude that PET with FDG has potential as a diagnostic modality for detection of primary breast cancer, particularly in the patient with radiodense breasts by conventional mammography, and that it has potential for the preoperative identification of axillary lymph node metastases.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalAnnals of Surgery
Volume216
Issue number1
StatePublished - Jul 1992
Externally publishedYes

Fingerprint

Breast Diseases
Positron-Emission Tomography
Electrons
Breast
Lymph Nodes
Deoxyglucose
Breast Neoplasms
Biochemical Phenomena
Neoplasm Metastasis
Mammography
Isotopes
Clinical Trials

ASJC Scopus subject areas

  • Surgery

Cite this

Tse, N. Y., Hoh, C. K., Hawkins, R. A., Zinner, M. J., Dahlbom, M., Choi, Y., ... Glaspy, J. A. (1992). The application of positron emission tomographic imaging with fluorodeoxyglucose to the evaluation of breast disease. Annals of Surgery, 216(1), 27-34.

The application of positron emission tomographic imaging with fluorodeoxyglucose to the evaluation of breast disease. / Tse, Nielson Y.; Hoh, Carl K.; Hawkins, Randall A.; Zinner, Michael J.; Dahlbom, Magnus; Choi, Yong; Maddahi, Jamshid; Brunicardi, F. Charles; Phelps, Michael E.; Glaspy, John A.

In: Annals of Surgery, Vol. 216, No. 1, 07.1992, p. 27-34.

Research output: Contribution to journalArticle

Tse, NY, Hoh, CK, Hawkins, RA, Zinner, MJ, Dahlbom, M, Choi, Y, Maddahi, J, Brunicardi, FC, Phelps, ME & Glaspy, JA 1992, 'The application of positron emission tomographic imaging with fluorodeoxyglucose to the evaluation of breast disease', Annals of Surgery, vol. 216, no. 1, pp. 27-34.
Tse NY, Hoh CK, Hawkins RA, Zinner MJ, Dahlbom M, Choi Y et al. The application of positron emission tomographic imaging with fluorodeoxyglucose to the evaluation of breast disease. Annals of Surgery. 1992 Jul;216(1):27-34.
Tse, Nielson Y. ; Hoh, Carl K. ; Hawkins, Randall A. ; Zinner, Michael J. ; Dahlbom, Magnus ; Choi, Yong ; Maddahi, Jamshid ; Brunicardi, F. Charles ; Phelps, Michael E. ; Glaspy, John A. / The application of positron emission tomographic imaging with fluorodeoxyglucose to the evaluation of breast disease. In: Annals of Surgery. 1992 ; Vol. 216, No. 1. pp. 27-34.
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