The application of nanoparticles in gene therapy and magnetic resonance imaging

Fernando Herranz, Elena Almarza, Ignacio Rodríguez, Beatriz Salinas, Yamilka Rosell, Manuel Desco, Jeff W. Bulte, Jesús Ruiz-Cabello

Research output: Contribution to journalReview articlepeer-review

Abstract

The combination of nanoparticles, gene therapy, and medical imaging has given rise to a new field known as gene theranostics, in which a nanobioconjugate is used to diagnose and treat the disease. The process generally involves binding between a vector carrying the genetic information and a nanoparticle, which provides the signal for imaging. The synthesis of this probe generates a synergic effect, enhancing the efficiency of gene transduction and imaging contrast. We discuss the latest approaches in the synthesis of nanoparticles for magnetic resonance imaging, gene therapy strategies, and their conjugation and in vivo application.

Original languageEnglish (US)
Pages (from-to)577-591
Number of pages15
JournalMicroscopy Research and Technique
Volume74
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Bioimaging
  • Gene therapy
  • Iron oxide
  • Nanoparticles
  • Theranostic

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

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