The Application Of Hplc Chiral Stationary Phases To Pharmaceutical Analysis; The Resolution Of Some Tropic Acid Derivatives

Irving W. Wainer, Thomas D. Doyle, Christopher D. Breder

Research output: Contribution to journalArticlepeer-review

Abstract

A number of amide and ester derivatives of tropic acid were chromatographed by using a commercially available covalently bonded HPLC chiral stationary phase, (R)-N-(3>5-dinitrobenzoyl)-phenylglycine. The amide derivatives, including pharmacologically important tropicamide, were resolved on this column, but the ester derivatives, including atropine, were not.

Original languageEnglish (US)
Pages (from-to)731-741
Number of pages11
JournalJournal of Liquid Chromatography
Volume7
Issue number4
DOIs
StatePublished - Apr 1 1984

ASJC Scopus subject areas

  • Molecular Medicine

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