The apolipoprotein E ε4 allele is associated with blunting of ketamine-Induced psychosis in schizophrenia: A preliminary report

Anil K. Malhotra, Alan Breier, David Goldman, Lisa Picken, David Pickar

Research output: Contribution to journalArticle

Abstract

Interindividual differences in the psychotomimetic response to the N-methyl-d-aspartate receptor antagonist ketamine are commonly observed. The apolipoprotein E (APOE) ε4 allele has been associated with reduced severity of positive psychotic symptoms in schizophrenia. In this study, we sought to determine if the APOE ε4 allele influences the psychotomimetic response to ketamine in schizophrenics. Eighteen patients genotyped at the APOE locus underwent a double-blind infusion of ketamine and of placebo. Ketamine-induced alterations in the brief psychiatric rating scale factors were compared between schizophrenics with and without the APOE ε4 allele. APOE ε4+ schizophrenics displayed significantly reduced ketamine-induced psychosis, as compared to ε4- patients. These preliminary data indicate that the psychotomimetic response to ketamine may be genetically influenced and may provide additional evidence that APOE may modify expression of the positive symptoms in schizophrenia. Copyright (C) 1998 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalNeuropsychopharmacology
Volume19
Issue number5
DOIs
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Apolipoprotein E4
Ketamine
Psychotic Disorders
Schizophrenia
Alleles
Apolipoproteins E
Brief Psychiatric Rating Scale
Placebos

Keywords

  • APOE
  • Genotype
  • Ketamine
  • N-Methyl-d-aspartate
  • Psychosis

ASJC Scopus subject areas

  • Pharmacology

Cite this

The apolipoprotein E ε4 allele is associated with blunting of ketamine-Induced psychosis in schizophrenia : A preliminary report. / Malhotra, Anil K.; Breier, Alan; Goldman, David; Picken, Lisa; Pickar, David.

In: Neuropsychopharmacology, Vol. 19, No. 5, 11.1998, p. 445-448.

Research output: Contribution to journalArticle

Malhotra, Anil K. ; Breier, Alan ; Goldman, David ; Picken, Lisa ; Pickar, David. / The apolipoprotein E ε4 allele is associated with blunting of ketamine-Induced psychosis in schizophrenia : A preliminary report. In: Neuropsychopharmacology. 1998 ; Vol. 19, No. 5. pp. 445-448.
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