The anxiogenic β-carboline FG-7142 inhibits locomotor exploration similarly in postweanling and adult rats

George E. Jaskiw, Barbara K. Lipska, Daniel R. Weinberger

Research output: Contribution to journalArticle

Abstract

The β-carboline FG-7142 exerts many stress-like effects in the adult rat, including the inhibition of locomotor exploration. However, comparable effects in immature animals have not been reported. Stress-like effects of FG-7142 are mediated via its inverse agonist actions on gamma-aminobutyric acid (GABA) receptors. GABA systems change considerably with development and GABA agonists such as diazepam have opposite behavioral actions in immature and adult rats. Accordingly, we compared FG-7142 effects on locomotor exploration in postweanling and adult rats. Postweanling male rats (24 days) and adult rats (90 days) received a single injection of vehicle or FG-7142 (15 mg/kg i.p.) and 15 min later were placed in photocell monitors for 1 h. Although postweanling animals traveled a smaller distance overall than adults, FG-7142 inhibited locomotor exploration to a similar degree in both groups. We conclude that FG-7142 exerts stress-like effects in postweanling rats and may be considered for use as a model of childhood stress.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume346
Issue number1-2
DOIs
StatePublished - Jul 31 2003
Externally publishedYes

Keywords

  • Development
  • Gamma-Aminobutyric acid
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

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