The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Latently infected resting memory CD4+ T cells represent a major barrier to HIV-1 eradication. Studies have shown that it will not be possible to cure HIV-1 infection unless these cells are eliminated. Latently infected cells probably do not express viral antigens and thus may not be susceptible to the HIV-1 specific immune response, nevertheless the size and composition of the reservoir is influenced by the immune system. In this chapter, we review the different components of the HIV-1 specific immune response and discuss how the immune system can be harnessed to eradicate the virus.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages43-67
Number of pages25
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume417
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Terilli Veenhuis, R., & Blankson, J. N. (2018). The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir. In Current Topics in Microbiology and Immunology (pp. 43-67). (Current Topics in Microbiology and Immunology; Vol. 417). Springer Verlag. https://doi.org/10.1007/82_2017_72