The antineutrophil cytoplasmic antibody-associated vasculitides

Philip Seo, John H. Stone

Research output: Contribution to journalReview articlepeer-review


Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome are small- to medium-vessel vasculitides linked by overlapping pathology and the presence of antineutrophil cytoplasmic antibodies (ANCA). Commonly referred to as the ANCA-associated vasculitides, these diseases are challenging to diagnose and to treat. Distinguishing the ANCA-associated vasculitides from other forms of vasculitis or nonvasculitic processes (such as infection) can be particularly difficult. This review describes the clinical and pathologic hallmarks of the ANCA-associated vasculitides, discusses the role of ANCA assays in diagnosis and treatment, and outlines an approach to the evaluation and management of these diseases.

Original languageEnglish (US)
Pages (from-to)39-50
Number of pages12
JournalAmerican Journal of Medicine
Issue number1
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Medicine(all)


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