The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel

Yi Liu, Zhong Zheng, Janette N. Zara, Chingyun Hsu, Donnalisa E. Soofer, Kevin S. Lee, Ronald K. Siu, Lloyd S. Miller, Xinli Zhang, Doug Carpenter, Chunling Wang, Kang Ting, Chia Soo

Research output: Contribution to journalArticlepeer-review

Abstract

Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/. poly (dl-lactic- co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.

Original languageEnglish (US)
Pages (from-to)8745-8756
Number of pages12
JournalBiomaterials
Volume33
Issue number34
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • Antimicrobial osteoinductive
  • Implant-associated infections
  • Poly(dl-lactic-co-glycolic acid) (PLGA)
  • Silver nanoparticle
  • Silver nanoparticle/poly(dl-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA)

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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