The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation

Medicine & Life Sciences

• Acyclovir 73%
• RNA-Directed DNA Polymerase 71%
• Multiple Drug Resistance 64%
• Virus Replication 61%
• HIV 42%
• Mutation 34%
• Simplexvirus 30%
• Pharmaceutical Preparations 25%
• HIV Reverse Transcriptase 17%
• acyclovir triphosphate 10%
• deoxyguanosine triphosphate 8%
• Guanosine 6%
• Reverse Transcriptase Inhibitors 6%
• Nucleosides 5%
• Viral Load 5%
• Lead 5%
• Inhibitory Concentration 50 5%
• Antiviral Agents 4%
• Virus Diseases 4%
• Clinical Studies 3%
• Therapeutics 3%
• DNA 3%

Chemical Compounds

• Acyclovir 86%
• Mutation 51%
• Resistance 38%
• Drug 32%
• dGTP 10%
• Antiviral Drug 9%
• Nucleoside Analogue 8%
• Guanosine 7%
• Pressure 3%