The anthelmintic drug mebendazole inhibits growth, migration and invasion in gastric cancer cell model

Laine Celestino Pinto, Bruno Moreira Soares, João de Jesus Viana Pinheiro, Gregory J. Riggins, Paulo Pimentel Assumpção, Rommel Mário Rodriguez Burbano, Raquel Carvalho Montenegro

Research output: Contribution to journalArticlepeer-review

Abstract

The present study aimed to investigate the effects of MBZ on a human malignant ascites cell line derived from a primary gastric cancer tumor. Our data reveal that MBZ showed high cytotoxicity in vitro, displaying an IC50 of 0.39μM and 1.25μM in ACP-02 and ACP-03, respectively. The association between MBZ and 5-FU increased slightly the cytotoxicity when compared to MBZ and 5-FU alone. Furthermore, MBZ disrupted the microtubule structure of AGP-01 cells and inhibited significantly the invasion and migration of these cells. Activity of active MMP-2 significantly decreased at all tested concentration of MBZ compared to negative control. These results support the indication of MBZ in combination with chemotherapeutic agents as a possible adjuvant therapy for the management/treatment of patients with advanced gastric cancer since MBZ is a drug of low cost with acceptable safety profile and reduced toxicity to normal cells. However, clinical trials must be performed in o to evaluate its efficacy in gastric cancer patients.

Original languageEnglish (US)
Pages (from-to)2038-2044
Number of pages7
JournalToxicology in Vitro
Volume29
Issue number8
DOIs
StatePublished - Dec 1 2015

Keywords

  • Invasion
  • Mebendazole
  • Metalloproteinase
  • Migration

ASJC Scopus subject areas

  • Toxicology

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