The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts

Louis Dore-Savard, Esak Lee, Samata Kakkad, Aleksander S Popel, Zaver M Bhujwalla

Research output: Contribution to journalArticle

Abstract

The plasticity of cancer cells and the fluidity of the tumor microenvironment continue to present major challenges in the comprehensive understanding of cancer that is essential to design effective treatments. The tumor interstitial fluid (TIF) encompasses the secretome and holds the key to several of the phenotypic characteristics of cancer. Difficulties in sampling this fluid have resulted in limited characterization of its components. Here we have sampled TIF from triple negative and estrogen receptor (ER)-positive human breast tumor xenografts with or without VEGF overexpression. Angiogenesis-related factors were characterized in the TIF and plasma, to understand the relationship between the TIF and plasma secretomes. Clear differences were observed between the TIF and plasma angiogenic secretomes in triple negative MDA-MB-231 breast cancer xenografts compared to ER-positive MCF-7 xenografts with or without VEGF overexpression that provide new insights into TIF components and the role of VEGF in modifying the angiogenic secretome.

Original languageEnglish (US)
Article number39460
JournalScientific Reports
Volume6
DOIs
StatePublished - Dec 20 2016

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Heterografts
Vascular Endothelial Growth Factor A
Extracellular Fluid
Breast Neoplasms
Neoplasms
Estrogen Receptors
Tumor Microenvironment
Angiogenesis Inducing Agents

ASJC Scopus subject areas

  • General

Cite this

The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts. / Dore-Savard, Louis; Lee, Esak; Kakkad, Samata; Popel, Aleksander S; Bhujwalla, Zaver M.

In: Scientific Reports, Vol. 6, 39460, 20.12.2016.

Research output: Contribution to journalArticle

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