The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon

Jean K. Carr, Judith N. Torimiro, Nathan D. Wolfe, Mpoudi Ngole Eitel, Bohye Kim, Eric Sanders-Buell, Linda L. Jagodzinski, Deanna Gotte, Donald S. Burke, Deborah L. Birx, Francine E. McCutchan

Research output: Contribution to journalArticle

Abstract

The genetic diversity of group M HIV-1 is highest in west central Africa. Blood samples from four locations in Cameroon were collected to determine the molecular epidemiology of HIV-1. The C2-V5 region of envelope was sequenced from 39 of the 40 samples collected, and 7 samples were sequenced across the genome. All strains belonged to group M of HIV-1. The circulating recombinant form CRF02_AG (IbNG) was the most common strain (22/39, 56%). Two of these were confirmed by full genome analysis. Four samples (4/39, 10%) clustered with the sub-subtype F2 and one of these was confirmed by full genome sequencing. Recombinant forms, each different but containing subtype A, accounted for the next most common form (7/39, 18%). Among these recombinants, those combining subtypes A and G were the most common (4/7, 57%). Also found were 3 subtype A, 2 subtype G, and 1 subtype B strain. Many recombination break points were shared between IbNG and the other AG recombinants, though none of these other AG recombinants included IbNG as a parent. This suggests that there was an ancestral AG recombinant that gave rise to CRF02_AG (IbNG), the successful circulating recombinant form, and to others that were less successful and are now rare.

Original languageEnglish (US)
Pages (from-to)168-181
Number of pages14
JournalVirology
Volume286
Issue number1
DOIs
StatePublished - Jul 20 2001

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Cameroon
HIV-1
Genome
Central Africa
Western Africa
Molecular Epidemiology
Genetic Recombination

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Carr, J. K., Torimiro, J. N., Wolfe, N. D., Eitel, M. N., Kim, B., Sanders-Buell, E., ... McCutchan, F. E. (2001). The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon. Virology, 286(1), 168-181. https://doi.org/10.1006/viro.2001.0976

The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon. / Carr, Jean K.; Torimiro, Judith N.; Wolfe, Nathan D.; Eitel, Mpoudi Ngole; Kim, Bohye; Sanders-Buell, Eric; Jagodzinski, Linda L.; Gotte, Deanna; Burke, Donald S.; Birx, Deborah L.; McCutchan, Francine E.

In: Virology, Vol. 286, No. 1, 20.07.2001, p. 168-181.

Research output: Contribution to journalArticle

Carr, JK, Torimiro, JN, Wolfe, ND, Eitel, MN, Kim, B, Sanders-Buell, E, Jagodzinski, LL, Gotte, D, Burke, DS, Birx, DL & McCutchan, FE 2001, 'The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon', Virology, vol. 286, no. 1, pp. 168-181. https://doi.org/10.1006/viro.2001.0976
Carr JK, Torimiro JN, Wolfe ND, Eitel MN, Kim B, Sanders-Buell E et al. The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon. Virology. 2001 Jul 20;286(1):168-181. https://doi.org/10.1006/viro.2001.0976
Carr, Jean K. ; Torimiro, Judith N. ; Wolfe, Nathan D. ; Eitel, Mpoudi Ngole ; Kim, Bohye ; Sanders-Buell, Eric ; Jagodzinski, Linda L. ; Gotte, Deanna ; Burke, Donald S. ; Birx, Deborah L. ; McCutchan, Francine E. / The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon. In: Virology. 2001 ; Vol. 286, No. 1. pp. 168-181.
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