The Adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis

Brian R. Lindman, Suzanne V. Arnold, Jose Madrazo, Alan Zajarias, Stephanie N. Johnson, Julio E. Pérez, Douglas L. Mann

Research output: Contribution to journalArticle

Abstract

Background-The diabetic heart exhibits increased left ventricular (LV) mass and reduced ventricular function. However, this relationship has not been studied in patients with aortic stenosis (AS), a disease process that causes LV hypertrophy and dysfunction through a distinct mechanism of pressure overload. The aim of this study was to determine how diabetes mellitus (DM) affects LV remodeling and function in patients with severe AS. Methods and Results-Echocardiography was performed on 114 patients with severe AS (mean aortic valve area [AVA], 0.6 cm2) and included measures of LV remodeling and function. Multivariable linear regression models investigated the independent effect of DM on these aspects of LV structure and function. Compared to patients without diabetes (n=60), those with diabetes (n=54) had increased LV mass and LV end-systolic and end-diastolic dimensions, and decreased LV ejection fraction (EF) and longitudinal systolic strain (all P

Original languageEnglish (US)
Pages (from-to)286-292
Number of pages7
JournalCirculation: Heart Failure
Volume4
Issue number3
DOIs
StatePublished - May 2011
Externally publishedYes

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Ventricular Remodeling
Aortic Valve Stenosis
Left Ventricular Function
Diabetes Mellitus
Linear Models
Ventricular Function
Left Ventricular Dysfunction
Left Ventricular Hypertrophy
Aortic Valve
Stroke Volume
Echocardiography
Pressure

Keywords

  • Aortic valve stenosis
  • Diabetes mellitus
  • Echocardiography
  • Hypertrophy left ventricular
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

The Adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis. / Lindman, Brian R.; Arnold, Suzanne V.; Madrazo, Jose; Zajarias, Alan; Johnson, Stephanie N.; Pérez, Julio E.; Mann, Douglas L.

In: Circulation: Heart Failure, Vol. 4, No. 3, 05.2011, p. 286-292.

Research output: Contribution to journalArticle

Lindman, Brian R. ; Arnold, Suzanne V. ; Madrazo, Jose ; Zajarias, Alan ; Johnson, Stephanie N. ; Pérez, Julio E. ; Mann, Douglas L. / The Adverse impact of diabetes mellitus on left ventricular remodeling and function in patients with severe aortic stenosis. In: Circulation: Heart Failure. 2011 ; Vol. 4, No. 3. pp. 286-292.
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