The 119 non-splinted vasovasostomies performed on 95 rats demonstrated sperm granulomas in 99% of the 49 anastomoses that failed. Anastomoses performed on vasa that contained no sperm resulted in 95% patency without granulomas. This procedure was accomplished in immature animals followed to adulthood or by testosterone suppression of spermatogenesis in adult rats. Alternatively, normal adults with sperm in the vasa were irrigated with normal saline at the time of vasovasostomy and this resulted in a decreased number of granulomas and distinctly improved the success rates. Sperm granuloma formation appears to be an important cause of failure of vasovasostomy in the rat.
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